Clay Margarave Armstrong (born 1934) is an American physiologist and a former student of Dr. Andrew Fielding Huxley. He is currently emeritus professor of Physiology at the University of Pennsylvania.
Armstrong was awarded the Louisa Gross Horwitz Prize from Columbia University in 1996, and the Albert Lasker Award for Basic Medical Research (shared with Bertil Hille and Roderick MacKinnon) in 1999. Armstrong was elected a Fellow of the American Academy of Arts and Sciences in 1999. He won the 2001 Gairdner International Award.
Armstrong is married to noted scientist Clara Franzini-Armstrong.
Ideas and influence
Much of the current understanding of ion channel structure and function can be attributed to the work of Clay Armstrong. Armstrong provided the first general description of the K+ ion channel pore, including the fundamental ideas of a selectivity filter that can allow the rapid flow of K+ while excluding the flow of Na+ across the cell membrane; a wide inner vestibule; and a molecular gating element at the cytoplasmic side of the channel that controls the flow of ions through the pore. In addition, Armstrong's studies (with Francisco Bezanilla) that described the first measurement of charge movement associated with the activation of Na+-selective ion channels laid the groundwork for the current understanding of the molecular basis of electrical signaling in nerve and muscle cells.
A consistent feature of Armstrong's contributions is the quantitative nature of his work, combined with clear and concise descriptions of the underlying mechanism.
- "Book of Members, 1780-2010: Chapter A". American Academy of Arts and Sciences. Retrieved 25 April 2011.
- "Clay M Armstrong, MD web page".
- Lasker Award
- "Inactivation of the Potassium Conductance and Related Phenomena Caused by Quaternary Ammonium Ion Injection in Squid Axons".
- "Charge movement associated with the opening and closing of the activation gates of the Na channels.".
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