Clobenpropit

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Clobenpropit
Clobenpropit.svg
Systematic (IUPAC) name
N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
Clinical data
Legal status ?
Identifiers
CAS number 145231-45-4
ATC code None
PubChem CID 2790
IUPHAR ligand 1223
ChemSpider 2688
ChEMBL CHEMBL14690
Chemical data
Formula C14H17ClN4S 
Mol. mass 308.83 g/mol

Clobenpropit is a histamine H3 receptor antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]

See also[edit]

References[edit]

  1. ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431. 
  2. ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology 563 (1-3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.