Clofoctol

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Clofoctol
Clofoctol.svg
Systematic (IUPAC) name
2-[(2,4-dichlorophenyl)methyl]-
4-(2,4,4-trimethylpentan-2-yl)phenol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Routes Rectal (suppository)[1]
Pharmacokinetic data
Bioavailability 98%[1]
Metabolism Hepatic glucuronidation[1]
Excretion Biliary[1]
Identifiers
CAS number 37693-01-9 YesY
ATC code J01XX03
PubChem CID 2799
ChemSpider 2697 YesY
UNII 704083NI0R YesY
KEGG D07244 YesY
ChEMBL CHEMBL1476605
Chemical data
Formula C21H26Cl2O 
Mol. mass 365.336 g/mol
 YesY (what is this?)  (verify)

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.[2]

It penetrates into human lung tissue.[3]

References[edit]

  1. ^ a b c d e "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. Retrieved 2007-08-10. 
  2. ^ Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]". J Pharmacol (in French) 11 (4): 411–25. PMID 6782374. 
  3. ^ Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res 14 (1): 39–43. PMID 3391105.