Clopamide

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Clopamide
Clopamide.svg
Clopamide ball-and-stick.png
Systematic (IUPAC) name
4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 636-54-4 YesY
ATC code C03BA03
PubChem CID 2804
ChemSpider 2702 YesY
UNII 17S83WON0I YesY
KEGG D02460 YesY
ChEMBL CHEMBL1361347 N
Chemical data
Formula C14H20ClN3O3S 
Mol. mass 345.846 g/mol
 N (what is this?)  (verify)

Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]

Mechanism of action[edit]

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References[edit]

  1. ^ McNeil, J. J.; Conway, E. L.; Drummer, O. H.; Howes, L. G.; Christophidis, N.; Louis, W. J. (1987). "Clopamide: Plasma concentrations and diuretic effect in humans". Clinical pharmacology and therapeutics 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784.  edit