Clopamide
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| Systematic (IUPAC) name | |
| 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl- benzamide |
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| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 636-54-4 |
| ATC code | C03BA03 |
| PubChem | CID 2804 |
| ChemSpider | 2702  |
| UNII | 17S83WON0I |
| KEGG | D02460 |
| Chemical data | |
| Formula | C14H20ClN3O3S |
| Mol. mass | 345.846 g/mol |
| SMILES | eMolecules & PubChem |
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Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]
[edit] Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.[2] It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.[3]
[edit] References
- ^ McNeil, J. J.; Conway, E. L.; Drummer, O. H.; Howes, L. G.; Christophidis, N.; Louis, W. J. (1987). "Clopamide: Plasma concentrations and diuretic effect in humans". Clinical pharmacology and therapeutics 42 (3): 299–304. PMID 3621784.
- ^ Erina, E. V.; Luk'Ianova, O. N.; Dzhappuev, A. D.; Serebrovskaia, I.; Bronshteĭn, R. I. (1971). "Study of the therapeutic effect and mechanism of action of a new diuretic, Brinaldix, in hypertension". Terapevticheskii arkhiv 43 (1): 68–72. PMID 5574542.
- ^ Duarte, J. D.; Cooper-Dehoff, R. M. (2010). "Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics". Expert Review of Cardiovascular Therapy 8 (6): 793–802. doi:10.1586/erc.10.27. PMC 2904515. PMID 20528637. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2904515.
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