Cloroqualone

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Cloroqualone
Cloroqualone.svg
Systematic (IUPAC) name
3-(2,6-Dichlorophenyl)-2-ethyl-4-quinazolinone
Clinical data
Pregnancy cat.
  •  ?
Legal status
?
Routes ?
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half-life ?
Excretion ?
Identifiers
CAS number 25509-07-3 N
ATC code None
PubChem CID 63338
DrugBank ?
ChemSpider 57005 YesY
UNII 172D4Q6LOW YesY
ChEMBL CHEMBL2106114 N
Chemical data
Formula C16H12Cl2N2O 
Mol. mass 319.185
 N (what is this?)  (verify)

Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.

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