The closing capacity (CC) is the volume in the lungs at which its smallest airways, the alveoli collapse. The alveoli lack supporting cartilage and so depend on other factors to keep them open. The closing capacity is greater than the residual volume (RV), the amount of gas that normally remains in the lungs during respiration, and specifically, after forced expiration. This is because closing capacity is equal to closing volume plus residual volume. This means that there is normally enough air within the lungs to keep these airways open throughout both inhalation and exhalation. As the lungs age, there is a gradual increase in the closing capacity. This also occurs with certain disease processes, such as asthma, chronic obstructive pulmonary disease, and pulmonary edema. Any process that increases the CC by lowering the functional residual capacity (FRC) can increase an individual's risk of hypoxemia, as the small airways may collapse during exhalation, leading to air trapping and atelectasis.
- Rodarte JR, Hyatt RE, Cortese DA (July 1975). "Influence of expiratory flow on closing capacity at low expiratory flow rates". J Appl Physiol 39 (1): 60–5. PMID 1150593.
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