The club was founded on 8 April 1907 when the representatives of Medicine, Engineering and Law Universities met at the Café Del Plata with the purpose of creating an athletic club, inspired by the institution founded in Medicine University a year before.
Universitario de Córdoba was a founding member of the Unión Cordobesa de Rugby, winning the first ever Cordobeso tournament's title in 1931. Universitario has won the most provincial championships with 20 titles, however its last win was in 1977. In recent years Uni have struggled to make an impact on the competition. Club's drop in form coinciding with the arrivals of much younger clubs such as Tala and La Tablada who have dominated cordobeso rugby since the 1970s.