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Combination of
Amiloride Potassium-sparing diuretic
Furosemide Loop diuretic
Clinical data
AHFS/ International Drug Names
Legal status
Routes Oral
CAS number  YesY
ATC code C03EB01
 N (what is this?)  (verify)

Co-amilofruse (BAN) is a nonproprietary name used to denote a combination of amiloride and the formerly named frusemide (now the INN termed furosemide). Co-amilofruse is a treatment for fluid retention (oedema), either in the legs (peripheral edema) or on the lungs (pulmonary oedema). The stronger furosemide loop diuretic has a tendency to cause low potassium levels (hypokalaemia) that may be prevented by the potassium-sparing effects of amiloride.


Two strengths of co-amilofruse are available:

  • 2.5 mg amiloride with 20 mg furosemide, BAN of Co-amilofruse 2.5/20 (brand name Frumil LS)
  • 5 mg amiloride with 40 mg furosemide, BAN of Co-amilofruse 5/4-0 (brand name Frumil)