|Traded as||NASDAQ: CDXS|
|Industry||biocatalysis, pharmaceuticals, industrial biotechnology, fine chemicals, biobased chemicals|
|Headquarters||Redwood City, CA, U.S.,
R&D facility Budapest, Hungary
|Key people||John J. Nicols Chief Executive Officer (CEO) and President
David D. O'Toole Senior Vice President and Chief Financial Officer
Douglas T.Sheehy Senior Vice President, General Counsel and Secretary
Jim Lalonde Vice President Research and Development
Scott Watson Vice President Sales and Marketing
Greg Hughes Vice President Alliance and New Product Development
|Revenue||US$107.1 million (FY 2010)|
|Employees||300 (as of March 2011)|
Codexis, Inc. engineers enzymes for pharmaceutical and chemical production. Codexis’ technologies enable scale-up and implementation of biocatalytic solutions to optimize process development, from research to manufacturing. There are currently over 50 pharmaceutical firms using Codexis’ technology, products and services in their manufacturing process development.
Codexis creates its products by applying its CodeEvolver® directed evolution technology platform, which introduces genetic mutations into microorganisms.
Pharmaceutical Enzymes, Intermediates and Services
Codexis markets and sells enzymes, development services and screening tools, providing manufacturing processes for active pharmaceutical ingredients (APIs), and their precursor pharmaceutical intermediates.
Codexis customers include major companies such as Merck, Pfizer, and Teva that use Codexis' custom biocatalysts to create more sustainable, less costly manufacturing processes for new and existing drugs. Codexis' biocatalysts are being used in the manufacturing process for the cholesterol-fighting drug Lipitor and are in development for the manufacturing of the diabetes drug Januvia. Codexis won the Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency (EPA) in 2006 for its work on a building block of Lipitor  and a second time with Merck in 2010 for its work on the active ingredient in Januvia.
Codex® Biocatalyst Panels and Kits
Codexis sells Codex® Biocatalyst Panels and Kits to companies who are engaged in both drug development and the marketing of approved drugs to allow them to screen and identify possible enzymatic manufacturing processes for their drug candidates and their marketed products. Codex® Biocatalyst Panels determine whether an enzyme produces a desired activity that is applicable to a particular process. 
For compounds that are in development, Codex® Biocatalyst Panels and Kits allow innovators to screen and identify possible enzymatic manufacturing processes rapidly and inexpensively for many of their drug candidates in-house, without the risks of disclosing the composition of their proprietary molecules before they have received patent protection. They also generate data that Codexis can use to optimize enzymes rapidly for a particular reaction, if necessary, reducing the time required to generate a manufacturing process capable of supporting clinical trials with inexpensively produced, pure drugs.
Enzyme screening services
Customers can send Codexis their materials to test against Codexis’ existing libraries of enzymes. If Codexis detects desired activity in a specific enzyme, it can supply the customer with this enzyme or perform optimization services to improve the performance of the enzyme. 
Codexis supplies varying quantities of its enzymes to pharmaceutical companies, from small to moderate quantities while they are optimizing their production processes, to larger quantities during later-stage clinical development and commercial scale drug production. Codexis also provides enzyme optimization services. 
Intermediates and APIs
Codexis supply intermediates and APIs made using enzymes.
Codexis engineers custom enzymes and microorganisms, which are sometimes referred to as biocatalysts. In simple terms, Codexis’ enzymes and microorganisms initiate or accelerate chemical reactions. Codexis' proprietary technology called CodeEvolver is directed evolution technology. It is based on the concept that natural genetic mutation and selection can be accelerated in the research laboratory to obtain specific improvements in the function of single proteins and multiprotein pathways. CodeEvolver combines DNA shuffling and bioinformatics with systems biology to create new biocatalysts.
Willem P.C. Stemmer, the inventor of DNA shuffling technology upon which Codexis was founded, and Frances H. Arnold, received the National Academy of Engineering's Charles Stark Draper Prize for their individual work on directed evolution technology.
Codexis is using its work in biofuels to develop sustainable sources for the 2 million ton detergent alcohol market. Detergent alcohols go into household products such as shampoo and conditioner. Approximately 70% of detergent alcohols are derived from palm kernel oil. The remaining 30% is derived from petroleum. The rising price and price volatility of palm oil and crude oil combined with environmental concerns have prompted consumer product companies to seek out sustainable alternatives.
Codexis has facilities in Redwood City, California and Budapest, Hungary. Codexis’ corporate headquarters is located in Redwood City, California and provides general administrative support to its business and is the center of Codexis’ manufacturing and research and development operations. In 2008, Codexis established its facilities in Budapest, Hungary to create a research and development center for microbial biocatalyst improvement and fermentation development
- "Codexis Overview". Retrieved 2011-04-03.
- Atkins, Randy (January 4, 2011). "'Directed evolution,' pioneer in DNA sequencing and designer of curricular program win honors". National Academy of Sciences.
- "Codexis enters detergent alcohols market". Retrieved 2011-03-04.
- Steenhuysen, Julie (June 17, 2010). "Greener approach to Januvia cuts costs, ups yield". Reuters.
http://ir.codexis.com/phoenix.zhtml?c=208899&p=irol-newsArticle&ID=1181061 http://www.reuters.com/article/2010/06/17/merck-green-idUSN1727061820100617 http://www.codexis.com/screening-tools http://www.codexis.com/screening_evolution http://www.codexis.com/codexis_products http://www.chemanager-online.com/en/topics/chemicals-distribution/codexis-sees-success-pharma-business?page=1 http://www.eurekalert.org/pub_releases/2011-01/naos-ep010411.php http://www.icis.com/blogs/green-chemicals/2011/03/codexis-enters-detergent-alcoh.html http://www.reuters.com/article/2010/06/17/merck-green-idUSN1727061820100617