Cofactor of BRCA1

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Negative elongation factor complex member B
Identifiers
Symbols NELFB ; COBRA1; NELF-B
External IDs OMIM611180 MGI1931035 HomoloGene121600 GeneCards: NELFB Gene
RNA expression pattern
PBB GE COBRA1 202757 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25920 58202
Ensembl ENSG00000188986 ENSMUSG00000013465
UniProt Q8WX92 Q8C4Y3
RefSeq (mRNA) NM_015456 NM_021393
RefSeq (protein) NP_056271 NP_067368
Location (UCSC) Chr 9:
140.15 – 140.17 Mb
Chr 2:
25.2 – 25.21 Mb
PubMed search [1] [2]

Cofactor of BRCA1, also known as COBRA1, is a human gene[1] that encodes NELF-B.

Function[edit]

NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660).[2] COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.[3]

Interactions[edit]

Cofactor of BRCA1 has been shown to interact with:

References[edit]

  1. ^ "Entrez Gene: COBRA1 cofactor of BRCA1". 
  2. ^ Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (2003). "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex". Molecular and Cellular Biology 23 (6): 1863–1873. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062. 
  3. ^ Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R (2001). "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations". The Journal of Cell Biology 155 (6): 911–922. doi:10.1083/jcb.200108049. PMC 2150890. PMID 11739404. 
  4. ^ Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R (Dec 2001). "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations". J. Cell Biol. 155 (6): 911–21. doi:10.1083/jcb.200108049. PMC 2150890. PMID 11739404. 
  5. ^ a b Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q (Dec 2004). "COBRA1 inhibits AP-1 transcriptional activity in transfected cells". Biochem. Biophys. Res. Commun. 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. PMID 15530430. 
  6. ^ Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R (Sep 2004). "Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor". Genes Dev. 18 (17): 2134–46. doi:10.1101/gad.1214104. PMC 515291. PMID 15342491. 
  7. ^ a b Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Mol. Cell. Biol. 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062. 
  8. ^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]