Cold urticaria

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Cold urticaria
Classification and external resources
Cold urticaria3.jpg
Allergic urticaria on leg in the form of hives induced by cold.
ICD-10 L50.2 (ILDS L50.210)
ICD-9 708.2
OMIM 120100
DiseasesDB 4688

Cold Urticaria (essentially meaning "cold hives") is an allergy where hives (urticaria) or large red welts form on the skin after exposure to a cold stimulus. The welts are usually itchy and often the hands and feet will become itchy and swollen as well. Hives vary in size from about 7mm in diameter to as big as about 27mm diameter or larger. The disease is classified as chronic when hives appear for longer than 6 weeks; they can last for life, though their course is often unpredictable. This disorder, or perhaps two disorders with the same clinical manifestations, can be inherited (familial cold urticaria) or acquired[1] (primary acquired cold urticaria). The acquired form is most likely to occur between ages 18–25.

Types[edit]

Cold urticaria may be divided into the following types:[2]

Primary cold contact urticaria[edit]

Primary cold contact urticaria is a cutaneous condition characterized by wheals, and occurs in rainy, windy weather, and after contact with cold objects, including ice cubes.[2]

Secondary cold contact urticaria[edit]

Secondary cold contact urticaria is a cutaneous condition characterized by wheals, due to serum abnormalities such as cryoglobulinemia or cryofibrinogenemia are extremely rare, and are then associated with other manifestations such as Raynaud's phenomenon or purpura.[2]

Reflex cold urticaria[edit]

Reflex cold urticaria is a cutaneous condition in which generalized cooling of the body induces widespread whealing.[2]

Familial cold urticaria[edit]

Familial cold urticaria
Classification and external resources
ICD-10 L50.2 (ILDS L50.220)
OMIM 120100
MeSH D056587

Familial cold urticaria (also properly known as familial cold autoinflammatory syndrome, FCAS) is an autosomal dominant condition characterized by rash, conjunctivitis, fever/chills and arthralgias[3] elicited by exposure to cold - sometimes temperatures below 22 °C (72 °F).[2][4]

It has been mapped to CIAS1[5] and is a slightly milder member of the disease family including Muckle–Wells syndrome and NOMID. It is rare and is estimated as having a prevalence of 1 per million people and mainly affects Americans and Europeans.[6]

FCAS is one of the cryopyrin-associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NALP3 (aka NLRP3) gene at location 1q44.[7][8][9] The disease was described in The Lancet Volume 364[10] by Hoffman H.M.[11] et al.

The effect of FCAS on the quality of life of patients is far reaching. A survey of patients in the United States in 2008 found, "To cope with their underlying disease and to try to avoid symptomatic, painful, flares patients reported limiting their work, school, family, and social activities. Seventy-eight percent of survey participants described an impact of the disease on their work, including absenteeism and impaired job advancement; frequently they quit their job as a consequence of their disease".[12]

Treatment using anakinra (Kineret) has been shown effective for FCAS although this does mean daily injections of the immunosuppressant into an area such as the lower abdomen.[13][14] The monoclonal antibody canakinumab (Ilaris) is also used.[15]

Symptoms[edit]

Hives on the back from exposure to cold air on an individual with cold allergy. The hives were induced by riding a stationary bike shirtless for an hour next to a door cracked open on a cool day. The temperature of the air flowing in was around 10C (50F). The lighter band at chest height was covered by a heart rate monitor strap.

When the body is exposed to the cold in individuals afflicted by the condition, hives appear and the skin in the affected area typically becomes itchy. Hives result from dilation of capillaries which allow fluid to flow out into the surrounding tissue which is the epidermis.They resolve when the body absorbs this fluid. The border of a hive is described as polycyclic, or made up of many circles, and changes as fluid leaks out and then is absorbed. Pressing on a hive causes the skin to blanch distinguishing it from a bruise or papule. Hives can last for a few minutes or a few days, and vary from person to person. Also a burning sensation occurs. During a severe reaction, hypotension, which can be life-threatening, can occur. A serious reaction is most likely to occur if the hives occur with less than 3 minutes of exposure (during a cold test).

Cause[edit]

The hives are a histamine reaction in response to cold stimuli, including a drastic drop in temperature, cold air, and cold water. There are many causes for cold hives, most are idiopathic (meaning they have no known cause). Some rare conditions[specify] can cause cold hives, and it can be useful to test for these conditions if the cold hives are in any way unusual.

Diagnosis[edit]

Diagnosis is typically obtained by an allergist or other licensed practitioner performing a cold test. During the cold test, a piece of ice is held against the forearm, typically for 2–3 minutes. A positive result is a specific looking mark of raised red hives. The hives may be the shape of the ice, or it may radiate from the contact area of the ice.

Treatment[edit]

The most important treatment is to stay warm. Some air conditioned rooms and pools may be too cold for the skin. Warming up immediately after exposure to cold temperatures usually helps control the hives before they get worse. Although the hives do not instantaneously disappear after warming the affected area(s), warming up afterwards reduces the time it takes for the hives to go away. Some patients report that spreading butter or vegetable shortening on their affected areas reduces the risk of future eruptions[citation needed].

Allergy medications containing antihistamines such as Benadryl, Zyrtec, Claritin, Periactin and Allegra may be taken orally to prevent and relieve some of the hives (depending on the severity of the allergy).[16] There are also topical antihistamine creams which are used to help relieve hives in other conditions, but there is not any documentation stating it will relieve hives induced by cold temperature.

Cold hives can result in a potentially serious, or even fatal, systemic reaction (anaphylactic shock). People with cold hives may have to carry an injectable form of epinephrine (like Epi-pen or Twinject) for use in the event of a serious reaction.

The best treatment for this allergy is avoiding exposure to cold temperature.

Ebastine has been proposed as an approach to prevent acquired cold urticaria.[17]

Situations when reactions may occur[edit]

  • Cold weather: Exposure to cold or cool air for more than a few minutes can trigger a reaction. Avoid long walks outdoors during cold weather. Be prepared to bundle up and cover exposed skin as long as the weather remains cool. Experiment to find the right number of layers.
  • Sweat: A reaction may even occur on a warm day when there is sweat on the skin. If there is a breeze it will rapidly cool the skin and create hives. Getting warm quickly by drying the skin and covering up will help to control the hives before they get too bad. Using or carrying a towel while exercising and wiping off sweat before it has a chance to dry is an effective means of preventing hives from occurring.
  • Cold/Cool IV Lines: While in the hospital, inserting IV lines that have been refrigerated or are cool into individuals who are allergic to cold temperature can/may result in pain within the limb the IV is placed and a line of hives may appear within a radius of 6-8 inches from the IV site in the pattern of a line going up the limb. Notify your doctor/nurse of your condition so they will be able to use a machine which warms IV lines before they enter your body
  • Swimming: Swimming can be especially dangerous as the rapid heart rate combined with the onset of hives can lead to hypotension. Taking an allergy medication before entering the water and conserving energy until your body adjusts to the temperature may help to prevent the hypotension. Take an antihistamine if you choose to go swimming; preferably a non-drowsy antihistamine, and have an individual with you at all times
  • Air Conditioning: Entering a cool building during a summer day can result in an allergic reaction to exposed areas of skin, congestion from breathing the cool air and possibly feeling fatigued. Carrying jackets with you on warm days is a good idea in case you enter an air conditioned building.
  • Cold Foods/Drinks: Eating or drinking cold or cool substances such as ice cream or even iced tea may result in the individuals tongue and surrounding tissues swelling. If eating cold foods or having cold drinks results in swelling of tissues in and around the mouth/throat it is advisable to take an antihistamine before consuming them and/or refraining from eating/drinking them.
  • Cool/Cold Surfaces: Sitting on sidewalks which are cool, leaning on or grabbing a cold pole will result in hives forming on the area which had contact with the cool surfaces. The only treatment for these kinds of situations is trying to avoid cold surfaces, if you can not avoid them using gloves to touch them or using a pad to sit on cool sidewalks is helpful
  • Restriction of Blood Flow: Typing or other activities which tense muscles and reduce blood flow can cool the body parts enough to cause itching and hives.
  • Blood Flow: While putting hands or feet in hot water nails turn purple/white until the body gets used to the temperature.

See also[edit]

References[edit]

  1. ^ Siebenhaar F, Weller K, : clinical picture and update on diagnosis and treatment (May 2007). "Acquired cold urticaria: Clinical picture and update on diagnosis and treatment". Clin. Exp. Dermatol. 32 (3): 241–5. doi:10.1111/j.1365-2230.2007.02376.x. PMID 17355280. 
  2. ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 267–8. ISBN 1-4160-2999-0. 
  3. ^ Tunca, Ozdogan, Mehmet, Huri. "Molecular and Genetic Characteristics of Hereditary Autoinflammatory". Molecular and Genetic Characteristics of Hereditary Autoinflammatory. Betham Science. Retrieved 12 April 2011. 
  4. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  5. ^ Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (November 2001). "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome". Nat. Genet. 29 (3): 301–5. doi:10.1038/ng756. PMID 11687797. 
  6. ^ Home Reference, Genetics. "Familial cold autoinflammatory syndrome". Familial cold autoinflammatory syndrome. U.S. National Library of Medicine. Retrieved 12 April 2011. 
  7. ^ CAPS, Community (2008-01-01). "Familial Cold Auto-inflammatory Syndrome (FCAS): Fact Sheet". Regeneron Pharmaceuticals. Retrieved 2010-02-01. 
  8. ^ HGNC, HUGO. "Gene Name Database". Gene Name Database. Wellcome Foundation. 
  9. ^ Protein Data Bank (PDB), RSCB. "1q44". Crystal Structure of an Arabidopsis Thaliana Putative Steroid Sulphotransferase. RCSB. Retrieved 12 April 2011. 
  10. ^ Hoffman H.M. et al, Vol 364. "Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist". Lancet Vol 364. The Lancet. 
  11. ^ Hoffman, Harold. "Associate Professor of Pediatrics and Medicine, UC San Diego". The prevention of cold-associated acute inflammation in cold auto-inflammatory syndrome by interleukin-1 receptor antagonist. The Lancet vol 364. 
  12. ^ Stych, B; Dobrovolny, D (2008). "Familial cold auto-inflammatory syndrome (FCAS): characterization of symptomatology and impact on patients' lives.". Curr Med Res Opin (Tarrytown, NY, USA : 2008) 24 (6): 1577–82. doi:10.1185/03007990802081543. PMID 18423104. 
  13. ^ Ross JB, et al; Finlayson, LA; Klotz, PJ; Langley, RG; Gaudet, R; Thompson, K; Churchman, SM; McDermott, MF; Hawkins, PN (2010-02-01). "Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up". Journal of cutaneous medicine and surgery 12 (1): 8–16. PMID 18258152. 
  14. ^ Samy K Metyas, Hal M Hoffman (2008-02-01). "Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.". Journal of Rheumatology. Retrieved 2010-02-01. 
  15. ^ Walsh, GM (2009). "Canakinumab for the treatment of cryopyrin-associated periodic syndromes". Drugs of today (Barcelona, Spain : 1998) 45 (10): 731–5. doi:10.1358/dot.2009.45.10.1436882. PMID 20069137. 
  16. ^ Mahmoudi M (May 2001). "Cold-induced urticaria". J Am Osteopath Assoc 101 (5 Suppl): S1–4. PMID 11409259. 
  17. ^ Magerl M, Schmolke J, Siebenhaar F, Zuberbier T, Metz M, Maurer M (December 2007). "Acquired cold urticaria symptoms can be safely prevented by ebastine". Allergy 62 (12): 1465–8. doi:10.1111/j.1398-9995.2007.01500.x. PMID 17900265. 

External links[edit]