Coldstream is a census-designated place (CDP) in southern Anderson Township, Hamilton County, Ohio, United States. The population was 1,173 at the 2010 census.
Coldstream is located at 39°2′54″N 84°20′57″W / 39.04833°N 84.34917°W / 39.04833; -84.34917 near the southeastern corner of Hamilton County. It is situated between Interstate 275 and the Ohio River. The CDP takes its name from the Coldstream Country Club and occupies the bluffs overlooking the Ohio River.
According to the United States Census Bureau, the CDP has a total area of 2.9 square miles (7.4 km2), of which 2.8 square miles (7.2 km2) is land and 0.077 square miles (0.2 km2), or 2.94%, is water.