Collagen, type XXV, alpha 1

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Collagen, type XXV, alpha 1
Identifiers
Symbols COL25A1 ; AMY; CLAC; CLAC-P; CLACP
External IDs OMIM610004 MGI1924268 HomoloGene57111 GeneCards: COL25A1 Gene
Orthologs
Species Human Mouse
Entrez 84570 77018
Ensembl ENSG00000188517 ENSMUSG00000058897
UniProt Q9BXS0 Q99MQ5
RefSeq (mRNA) NM_001256074 NM_001244952
RefSeq (protein) NP_001243003 NP_001231881
Location (UCSC) Chr 4:
109.73 – 110.22 Mb
Chr 3:
130.18 – 130.6 Mb
PubMed search [1] [2]

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[1][2]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][2]

Interactions[edit]

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[1]

References[edit]

  1. ^ a b Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537. 
  2. ^ a b "Entrez Gene: COL25A1 collagen, type XXV, alpha 1". 

Further reading[edit]