|Classification and external resources|
Micrograph of collagenous colitis. H&E stain.
Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak incidence in the 5th decade of life, affecting women more than men. Its clinical presentation involves watery diarrhea, usually in the absence of rectal bleeding. It is often classified under the umbrella entity microscopic colitis, along with a related condition, lymphocytic colitis.
On colonoscopy, the mucosa of the colon typically looks normal, but biopsies of affected tissue usually show deposition of collagen in the lamina propria, which is the area of connective tissue between colonic glands. Radiological tests, such as a barium enema are typically normal.
Microscopic colitis causes watery intermittent diarrhea with greater than 10 bowel movements per day. Some patients report nocturnal diarrhea, abdominal pain, dehydration and weight loss. Rare complications may include mucosal atrophy with long standing collagenous colitis. Though this is a mild condition, colitis patients report a significantly diminished quality of life.
The exact cause of collagenous colitis is unknown.
Treatment of collagenous colitis is often challenging, and many agents have been used therapeutically:
- Bismuth agents, including Pepto-Bismol
- 5-aminosalicylic acid
- Immunosuppressants, including azathioprine
Pilot investigational studies have shown some evidence of possible benefit for both Boswellia serrata extract and specific strains of probiotics in the treatment of collegenous colitis, although larger sample sizes are needed to confirm the results.
An association between collagenous colitis and celiac disease has been reported, but there is no evidence that dietary restrictions used in celiac disease management are of benefit in collagenous colitis therapy. Between 20-60% of patients with collagenous colitis have been reported as having one or more autoimmune disorders including rheumatoid arthritis and thyroid disease.
There have also been reports of an association between collagenous colitis and lymphoma.
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