Colombia–Uruguay relations are foreign relations between the Republic of Colombia and the Oriental Republic of Uruguay. Colombia has an embassy in Montevideo. Uruguay has an embassy in Bogotá and a consulate in Cali.
Historically, both countries were part of the Spanish Empire until the early 19th century. Nowadays, both countries are full members of the Rio Group, of the Latin Union, of ALADI, of the Association of Spanish Language Academies, of the Organization of American States, of the Organization of Ibero-American States, of the Community of Latin American and Caribbean States, of the Union of South American Nations, and of the Cairns Group.
Colombia is becoming a significant trading partner of Uruguay.