Coma cocktail

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The term coma cocktail refers to a combination of substances administered in an emergency to comatose individuals,[1] at a time when the cause of the coma in the individual was not yet known.

One combination included dextrose, flumazenil, naloxone, and thiamine.[2]

It has been suggested that the use of naloxone and flumazenil be administered more selectively than glucose and thiamine.[3]

Some have proposed that the concept be abandoned.[4]


  1. ^ Bartlett D (December 2004). "The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route". J Emerg Nurs 30 (6): 572–4. doi:10.1016/j.jen.2004.09.002. PMID 15565045. 
  2. ^ Doyon S, Roberts JR (May 1994). "Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine". Emerg. Med. Clin. North Am. 12 (2): 301–16. PMID 8187685. 
  3. ^ Buylaert WA (December 2000). "Coma induced by intoxication". Acta Neurol Belg 100 (4): 221–4. PMID 11233676. 
  4. ^ Bledsoe BE (November 2002). "No more coma cocktails. Using science to dispel myths & improve patient care". Journal of Emergency Medical Services 27 (11): 54–60. PMID 12483195.