The Combined Scottish Universities by-election, 1927 was a by-election held from 26 April to 29 April 1927 for the Combined Scottish Universities, a university constituency of the British House of Commons.
The seat had become vacant on 16 March 1927 when the Unionist Member of Parliament (MP) Sir Henry Craik, Bt. had died, aged 80. He had held the seat since its creation for the 1918 general election, having previously been MP for Glasgow and Aberdeen Universities.
Two candidates contested the by-election. John Buchan, the novelist, of the Unionist Party and Hugh B. Guthrie of the Labour Party, who had contested Glasgow Camlachie at the 1918 general election.
The result was a victory for Buchan, who won nearly 88% of the votes. He held the seat until 1935, when he resigned to take up the post of Governor General of Canada.