Combretastatin A-4 phosphate

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Combretastatin A-4 phosphate
Combretastatin A-4 phosphate.svg
Systematic (IUPAC) name
Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester
Clinical data
Legal status
CAS number  YesY
ATC code ?
PubChem CID 5351387
ChemSpider 4508406
Synonyms CA4P; CA4PD; fosbretabulin; fosbretabulin disodium
Chemical data
Formula C18H21O8P 
Molecular mass 396.32 g/mol (exact mass : 396.097404)
 YesY (what is this?)  (verify)
For more information about this drug and its actions, see combretastatin.

Combretastatin A-4 phosphate (fosbretabulin, and its salt fosbretabulin disodium) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. It is a derivative of combretastatin.

Combretastatin A-4 phosphate is a prodrug. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4.[1]