|Origin||Berks County, Pennsylvania|
|Length||61.6 miles (99.1 km)|
|Avg. discharge||670 cubic feet per second (19 m3/s)|
|Basin area||491 square miles (1,270 km2)|
Its headwaters rise mostly in southern Berks County (a small area rises in Chester County). The East Branch and West Branch of the Conestoga join to form the main river just north of Morgantown, and the stream flows from northeast to southwest for more than 60 miles (97 km), passing close to the center of Lancaster and ending at Safe Harbor along the Susquehanna River, approximately 16 miles (26 km) north of the Pennsylvania-Maryland state line.
The principal tributaries of the Conestoga River are Cocalico Creek, Mill Creek, and Little Conestoga Creek; they drain into the Conestoga River watershed in the order listed. The Conestoga River and its principal tributaries comprise approximately 114 stream miles, and they drain a watershed area of approximately 217 square miles (560 km2) if the main stream is alone considered, rising to 491 square miles (1,270 km2) when the Cocalico, Mill, and Little Conestoga Creek watersheds are also included.
The stream was named after a small tribe of the indigenous Iroquoian-speaking Susquehannock people, called the Susquehannocks by the English of Maryland and Virginia (an Algonquian name, Sasquesahanough, meaning "people of the muddy river") and the Conestoga by the English of Pennsylvania (from Kanastoge, meaning "place of the immersed pole", the name of their village in Pennsylvania). The village of Conestoga was reported to have two thousand inhabitants in the 17th century, and up to seven thousand people or more may have then lived in the watershed of the Conestoga River. By the early 18th century most of the Conestoga-Susquehannock were compelled to move to the Ohio area, where they gradually lost their distinctiveness as a nation. In 1763 the remaining Susquehannocks at Conestoga were attacked by the Paxton Boys, a group of anti-Indian vigilantes, who killed six of them at their village of Conestoga, and, two weeks later, despite official protection, killed fourteen of the remaining sixteen at the Lancaster workhouse. The two surviving Conestoga-Susquehannock worked as servants on a local farm until they died and were buried there.
The first steamboat in America floated on the stream in 1763. In the 19th century the name of the stream gained wider recognition with the spread of the Conestoga wagon, first built in and named after this valley. The wagon assisted the transportation of freight throughout the east, and later was adapted to help transport goods to the western frontier of the United States. So many cigars were made in the watershed in the late 19th century that a local cigar named the Conestoga became known as the stogie throughout the US. Though the stream is hardly the size generally designated a river, local boosterism in the late 19th century insisted that any stream holding scheduled commercial transport should be so called; steamboat service to a local amusement park along its banks barely qualified, but the designation caught on. The name Conestoga has also been applied to the Conestoga Rocket, a rocket produced from Minuteman I parts and launched from Matagorda Island, the ship Conestoga, which is a popular diving wreck in the Thousand Islands, the C-93 Conestoga cargo aircraft, and, in Star Trek, the name of the starship used in the failed first attempt at deep space colonization.
Land use along the stream has been traditionally agricultural, though spreading urbanization has affected the stream with erosion problems. Though extremely scenic, the Conestoga River is drastically impaired from nitrogen and phosphorus pollution, mostly runoff from animal waste and excessive commercial fertilizer. Other pollution sources are sediments from intense cropping, development, and urban runoff. The stream flows through a pastoral landscape farmed extensively by Pennsylvania German farmers and along the eastern and southern outskirts of the city of Lancaster. Many covered bridges span its banks. Northeast of Lancaster city are many Old Order Amish and Old Order Mennonite farms; horse and carriage traffic frequents local roads. Many small dams impound its waters, most of them built long ago to power mills or generate electricity. Most dams are in disrepair and have been abandoned, though there is an active movement to remove as many as possible. Seven were removed between 1996 and 1999.
- Covered bridges
- Hunsecker's Mill Covered Bridge 
- Pinetown Bushong's Mill Covered Bridge 
- Pool Forge Covered Bridge 
- Kurtz's Mill Covered Bridge , spanned the Conestoga River before it was moved to a new location
- Zook's Mill Covered Bridge , spans Cocalico Creek just upstream from its confluence with the Conestoga
- U.S. Geological Survey: PA stream gaging stations
- Map of old Conestoga River
- Aerial image of Conestoga River flowing east and south of Lancaster, PA
- Conestoga River near Slackwater, PA
- Little Conestoga Watershed Alliance
- Conestoga Trail map - northern section (Links to other sections of the trail are found on the right at this link.)
- summary description of Conestoga Trail
- another Conestoga Trail map