Congenital rubella syndrome

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Congenital rubella syndrome
Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores.jpg
White pupils due to congenital cataract in a child with congenital rubella syndrome
Classification and external resources
ICD-10 P35.0
ICD-9 771.0
DiseasesDB 11729
MedlinePlus 001658
eMedicine emerg/388
MeSH D012410

Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted rubella, usually in the first trimester. If infection occurs 0–28 days before conception, the infant has a 43% chance of being affected. If the infection occurs 0–12 weeks after conception, the chance increases to 51%. If the infection occurs 13–26 weeks after conception, the chance is 23% of the infant being affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.

It was discovered in 1941 by Australian Norman McAlister Gregg.


Congenital rubella serology time-line

The classic triad for congenital rubella syndrome is:

"Salt-and-pepper" retinopathy is the most common ocular manifestation of congenital rubella.

Other manifestations of CRS may include:

Children who have been exposed to rubella in the womb should also be watched closely as they age for any indication of:


Vaccination of women of childbearing age against rubella can prevent congenital rubella syndrome.


  1. ^ Oster ME, Riehle-Colarusso T, Correa A (January 2010). "An update on cardiovascular malformations in congenital rubella syndrome.". Clin Mol Teratol. 88 (1): 1–8. doi:10.1002/bdra.20621. PMID 19697432. 
  2. ^ Muhle, R; Trentacoste, SV; Rapin, I (May 2004). "The genetics of autism.". Pediatrics 113 (5): e472–86. doi:10.1542/peds.113.5.e472. PMID 15121991. 
  3. ^ Brown, A. S (9 February 2006). "Prenatal Infection as a Risk Factor for Schizophrenia". Schizophrenia Bulletin 32 (2): 200–202. doi:10.1093/schbul/sbj052. PMC 2632220. PMID 16469941. 

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