Conjugated linoleic acid
Conjugated linoleic acids (CLA) are a family of at least 28 isomers of linoleic acid found mostly in the meat and dairy products derived from ruminants. CLAs can be either cis- or trans-fats and the double bonds of CLAs are conjugated and separated by a single bond between them.
CLA is marketed as a dietary supplement on the basis of its supposed health benefits.
The biological activity of CLA was noted by researchers in 1979 who found it to inhibit chemically induced cancer in mice. In 2004, one of those researchers noted that the scientific literature was "growing at a phenomenal rate".
Most studies of CLAs have used a mixture of isomers wherein the isomers c9,t11-CLA (rumenic acid) and t10,c12-CLA were the most abundant. More recent studies using individual isomers indicate that the two isomers have very different health effects.
Conjugated linoleic acid is both a trans fatty acid and a cis fatty acid. The cis bond causes a lower melting point and ostensibly also the observed beneficial health effects. Unlike other trans fatty acids, it may have beneficial effects on human health. CLA is conjugated, and in the United States, trans linkages in a conjugated system are not counted as trans fats for the purposes of nutritional regulations and labeling. CLA and some trans isomers of oleic acid are produced by microorganisms in the rumens of ruminants. Non-ruminants, including humans, produce certain isomers of CLA from trans isomers of oleic acid, such as vaccenic acid, which is converted to CLA by delta-9-desaturase.
In healthy humans, CLA and the related conjugated linolenic acid (CLNA) isomers are bioconverted from linoleic acid and alpha-linolenic acid, respectively, mainly by Bifidobacterium bacteria strains inhabiting the gastrointestinal tract. However, this bioconversion may not occur at any significant level in those with a digestive disease, gluten sensitivity, and/or dysbiosis.
CLA is marketed in dietary supplement form for its supposed anti-cancer benefit (for which there is no evidence) and as a bodybuilding aid. A 2004 review of the evidence said that while CLA seemed to benefit non-human animals, there was a lack of good evidence of human health benefits, despite the many claims made for it.
CLA's potential benefit for overweight or obese people is questionable. While studies have shown no reduction in BMI for individuals taking the drug, small decreases in body fat have been noted. While the results are statistically significant, they were also small.
CLA has shown an effect on insulin response in diabetic rats but there is no evidence of this effect in humans.
Though in 2014 Shen et all reported in ′Influence of dietary Fat on intestinal microbes, inflammation, barrier function and metabolic outcomes′, that a '50:50 mix of conjugated linoic acid and fish oil enhanced the healing process of inflammatory bowel disease in pigs' based on a previous study in the Journal of Nutrition 2010
Kangaroo meat may have the highest concentration of CLA. Food products from grass-fed ruminants (e.g. mutton and beef) are good sources of CLA, and contain much more of it than those from grain-fed animals. In fact, meat and dairy products from grass-fed animals can produce 300-500% more CLA than those of cattle fed the usual diet of 50% hay and silage, and 50% grain.
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