He was born in the mid-12th century and the date of his death is unknown. From his own writings it is clear that he became a deacon and magister in the Patriarchal School of Constantinople. A little before 1204 he was promoted to the metropolitan bishopric of Cyzicus, which he had to relinquish shortly after the Latin conquest. Although most of what is known about Stilbes comes from his own works, Niketas Choniates does praise a certain "Stilbes, a good man in every regard" (ὁ καλὸς τὰ πάντα Στιλβὴς).
Stilbes' works pertain mostly to theology, the best known among scholars is his Errors of the Latin Church, which Stilbes compiled in the wake of the Fourth Crusade. The list describes western "errors," including their failure to honour foreign saints and their hatred of the Emperor Constantine for creating New Rome. Stilbes is also known for his poem describing a catastrophic fire that took place in Constantinople on July 25, 1197. Running to about a thousand lines, the Carmen de Incendio describes the course of the fire along the Golden Horn from the Gate of the Droungarios (Turkish: Odun Kapısı) through the Latin Quarter, using ekphrases rich with Biblical and Classical metaphors. The poem is an important resource for those studying the urban topography of Medieval Constantinople, as it describes the burning of three story houses and aristocratic houses with turrets, and it makes allusions to coastal roads, aqueducts, the Neorion Harbour, granaries, the Church of the Forty Martyrs, and the Church of the Theotokos Kyriotissa. Byzantinist Paul Magdalino has used the poem to date the medieval reconstruction of the Kyriotissa church to between the date of the fire in 1197 and the Fourth Crusade in 1204.
- Stilbes, Constantine; Johannes M. (Johannes Maria) Diethart, Wolfram Hörandner (2005). Constantinus Stilbes Poemata. Walter de Gruyter. p. vii. ISBN 978-3-598-71235-7.
- Niketas Choniates Epistula 10, 215,2.
- Abulafia, David (1999). The New Cambridge Medieval History c.1198-c.1300. Cambridge University Press. p. 542.
- Mottahedeh, Roy (2001). The Crusades from the Perspective of Byzantium and the Muslim World. Dumbarton Oaks. p. 117.
- Angold, Michael (2003). The Fourth Crusade: Event and Context. Longman. pp. 201–202.
- Kaldellis, Anthony (2008). Hellenism in Byzantium - The Transformations of Greek Identity and the Reception of the Classical Tradition. Cambridge University Press. p. 358. ISBN 978-0521876889.
- Vasiliev, Alexander (1971). History of the Byzantine Empire, 324-1453, Volume 2. University of Wisconsin Press. p. 502.
- Diethart and Hörandner (2005) p. 16.
- Diethart and Hörandner (2005) p. 24.
- Diethart and Hörandner (2005) p. 21.
- Diethart and Hörandner (2005) p. 27.
- Diethart and Hörandner (2005) p. 40.
- Diethart and Hörandner (2005) p. 15.
- Diethart and Hörandner (2005) p. 29.
- Paul Magdalino, "Constantinopolitana," Studies on the History and Topography of Byzantine Constantinople, (Ashgate, 2007) pp. 227-230.