Contraction band necrosis
Contraction band necrosis is a type of uncontrolled cell death (necrosis) unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture.
The name of the histopathologic finding comes from the appearance under the microscope; contraction bands are thick intensely eosinophilic staining bands (typically 4-5 micrometres wide) that span the short axis of the myocyte. They can be thought of extra thick striae, typical of cardiac muscle and striated muscle.
Contraction band necrosis is thought to arise by two mechanisms:
- a calcium-dependent mechanism - activation of the contractile machinery of the cell via its usual mechanism, calcium, which is in excess due to ischemia.
- a calcium-independent mechanism, as seen in rigor mortis - activation of the contractile machinery in the setting of low ATP.
Reperfusion associated cell death has been modulated (reduced) in animal studies and is an area of active research, which holds the potential to significantly reduce the morbidity (disease burden) and mortality (death) of cardiovascular disease.
- Rodríguez-Sinovas A, Abdallah Y, Piper HM, Garcia-Dorado D (December 2007). "Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction". Heart Fail Rev 12 (3-4): 207–16. doi:10.1007/s10741-007-9039-9. PMID 17530396.
- Garcia-Dorado D, Inserte J, Ruiz-Meana M, et al. (November 1997). "Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion". Circulation 96 (10): 3579–86. doi:10.1161/01.cir.96.10.3579. PMID 9396458.
- Contraction band necrosis - pathologypics.com