Copaiba is a stimulant oleoresin obtained from the trunk of several pinnate-leaved South American leguminous trees (genus Copaifera). The thick, transparent exudate varies in color from light gold to dark brown, depending on the ratio of resin to essential oil. Copaiba is used in making varnishes and lacquers.
The balsam may be steam distilled to give copaiba oil, a colorless to light yellow liquid with the characteristic odor of the balsam and an aromatic, slightly bitter, pungent taste. The oil consists primarily of sesquiterpene hydrocarbons; its main component is caryophyllene.
The hydrocarbons in copaiba are terpenes, which are made by plants from isoprene, a "five-carbon-atom building block, so they always contain carbon atoms in multiples of five. Pinene is one of several useful 10-carbon terpenes. It is commonly known as turpentine. Heated up, terpenes break down into methanol (CH3OH) and other simple compounds useful for fuel and as raw materials in the chemical industry."
Copaiba is also a common name for several species of trees of the legume family native to Tropical Africa and North and South America.
Copaiba is particularly interesting as a source of biodiesel, because of the high yield of 12,000 liters per ha. The resin is tapped from standing trees, with an individual tree yielding 40 liters per year. 
Copaiba has been used in traditional medicine.
Copaiba is also used as an artist material, especially in oil paint recipes and in ceramic decoration. Mineral painters use a medium made of copaiba, turpentine and lavender to mix with their minerals for adhesion to ceramic vessels before kiln firing. Copaiba makes a good medium for oils and helps with both adhesion and quality of shine.
Copaiba oil-resins extracted have been used medicinally dating back to the 16th century by the natives of north and northeastern Brazil. The folk remedies were administered orally or used as an ointment in the treatment of various diseases.
Industry and commerce
The production of Copaiba oil is socially significant to the Amazon because it represents approximately 95% of the country's oil-resin production industry. The Annual production of Copaiba oil in the Amazon is estimated to be 500 tons/year. The commercialization of Copaiba as an oil or in capsule form has grown due to demand by traditional and widespread use, and is exported to other countries, including the United States, France, and Germany.
Despite its usage in various pharmacological forms and wide use in folk medicine, Copaiba has not been officially registered as a phytochemical drug. Experiments to assess any cytotoxic and mutagenic potential of Copaiba-derived resin are underway in Brazil to determine safe usage, prior to phytochemical drug development. Under experimental conditions employed in a study on mice, it was concluded that the oil-resin from commercial Copaiba oil-resin showed no genotoxic or mutagenic effects.
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- Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice; Genetics and Molecular Biology. Mara Ribeiro Almeida, Joana D’Arc Castania Darin, Lívia Cristina Hernandes, Mônica Freiman de Souza Ramos, Lusânia Maria Greggi Antunes, Osvaldo de Freitas; Aug 2, 2012
- Antinociceptive activity of Amazonian Copaiba oils. Gomes NM1, Rezende CM, Fontes SP, Matheus ME, Fernandes PD
- In vitro evaluation of the genotoxic activity and apoptosis induction of the extracts of roots and leaves from the medicinal plant Coccoloba mollis (Polygonaceae) Tsuboy MS, Marcarini JC, Luiz RC, Barros IB, Ferreira DT, Ribeiro LR, Mantovani MS. J Med Food. 2010.
- Rupture point analysis of intestinal anastomotic healing in rats under the action of pure Copaíba (Copaifera Iangsdorfii) oil. Comelli Júnior E, Skinovski J, Sigwalt MF, Branco AB, Luz SR, Baulé Cde P. Acta Cir Bras. 2010 Aug; 25(4).
- Sustainability of extraction and production of copaiba (Copaifera multijuga Hayne) oleoresin in Manaus, AM, Brazil. (Medeiros and Vieira, 2008; Brazil, 2011). Medeiros RD, Vieira G. For Ecol Manage. 2008;256:282–288.
- Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil. Phytother Res. 2001 Sep; Zunino L, Calixto JB, Patitucci ML, Pinto AC.
- Genetic Molecular Biol. Genotoxicity Study 2012 Jul-Sep; 35(3): 664–672.