Copper fist

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Copper fist domain
PDB 1co4 EBI.jpg
Structure of a zinc domain conserved in yeast copper-regulated transcription factors.[1]
Identifiers
Symbol Copper fist
Pfam PF00649
InterPro IPR001083
SMART SM00412
PROSITE PS50073
SCOP 1co4
SUPERFAMILY 1co4

Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist.

It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.

External links[edit]

References[edit]

  1. ^ Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR (July 1998). "Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors". Nat. Struct. Biol. 5 (7): 551–5. doi:10.1038/805. PMID 9665167.