|Jmol-3D images||Image 1|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). Famous for the bitter taste that it produces, it is used in Chinese herbal medicine along with the related compound berberine for treating digestive disorders caused by bacterial infections.
Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant. However, this may also imply a hazard for those taking other medications or with a natural functional disorder in Monoamine oxidase A.
Coptisine was found to be toxic to larval brine shrimp and a variety of human cell lines, potentially implying a therapeutic effect on cancer or alternatively a generally toxic character. The same authors illustrate a four-step process to produce Coptisine from Berberine.
- Complementary and Alternative Healing University (Chinese Medicine)[unreliable medical source?]
- Hakim, Sohrab A. E.; Mijović, Valerie; Walker, James (1961). "Distribution of Certain Poppy-Fumaria Alkaloids and a Possible Link with the Incidence of Glaucoma". Nature 189 (4760): 198–201. doi:10.1038/189198a0. PMID 13710637.
- Ro, Jai Seup; Lee, Sang Seon; Lee, Kyong Soon; Lee, Myung Koo (2001). "Inhibition of type a monoamine oxidase by coptisine in mouse brain". Life Sciences 70 (6): 639–45. doi:10.1016/S0024-3205(01)01437-0. PMID 11833714.
- Colombo, Maria Laura; Bugatti, Carlo; Mossa, Andrea; Pescalli, Nicoletta; Piazzoni, Laura; Pezzoni, Gabriella; Menta, Ernesto; Spinelli, Silvano et al. (2001). "Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine". Il Farmaco 56 (5–7): 403–9. doi:10.1016/S0014-827X(01)01121-1. PMID 11482767.
|This article about an alkaloid is a stub. You can help Wikipedia by expanding it.|