Cord colitis syndrome

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Cord colitis syndrome is a diarrheal illness in recipients of umbilical cord blood transplant. It causes a granulomatous inflammation of the upper and lower gastrointestinal tract and responds to antimicrobial treatment including metronidazole.[1] It was first described in 2011.[2] In 2013, a sequencing study identified a newly discovered bacterium, called Bradyrhizobium enterica, in biopsy samples from two patients. That this bacterium is responsible for this syndrome can be suggested, but not yet confirmed.[3]

References[edit]

  1. ^ Gupta, NK; Masia, R (July 2013). "Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.". The American journal of surgical pathology 37 (7): 1109–13. doi:10.1097/pas.0b013e31828a827a. PMID 23715165. 
  2. ^ Bhatt, AS; Freeman, SS; Herrera, AF; Pedamallu, CS; Gevers, D; Duke, F; Jung, J; Michaud, M; Walker, BJ; Young, S; Earl, AM; Kostic, AD; Ojesina, AI; Hasserjian, R; Ballen, KK; Chen, YB; Hobbs, G; Antin, JH; Soiffer, RJ; Baden, LR; Garrett, WS; Hornick, JL; Marty, FM; Meyerson, M (Aug 8, 2013). "Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome.". The New England journal of medicine 369 (6): 517–28. doi:10.1056/nejmoa1211115. PMID 23924002. 
  3. ^ Bhatt, AS; Freeman, SS; Herrera, AF; Pedamallu, CS; Gevers, D; Duke, F; Jung, J; Michaud, M; Walker, BJ; Young, S; Earl, AM; Kostic, AD; Ojesina, AI; Hasserjian, R; Ballen, KK; Chen, YB; Hobbs, G; Antin, JH; Soiffer, RJ; Baden, LR; Garrett, WS; Hornick, JL; Marty, FM; Meyerson, M (Aug 8, 2013). "Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome.". The New England journal of medicine 369 (6): 517–28. doi:10.1056/nejmoa1211115. PMID 23924002.