Cordycepin

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Cordycepin
Cordycepin.svg
Identifiers
CAS number 73-03-0 N
PubChem 6303
ChemSpider 6064 N
ChEMBL CHEMBL305686 N
Jmol-3D images Image 1
Image 3
Properties
Molecular formula C10H13N5O3
Molar mass 251.24 g mol−1
Melting point 225.5 °C (437.9 °F; 498.6 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of oxygen in the 3' position of its ribose part. It was initially extracted from fungi of genus Cordyceps, but is now produced synthetically.

Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two. Therefore, it can participate in certain biochemical reactions (for example, be incorporated into an RNA molecule, thus causing the premature termination of its synthesis).[1][2]

See also[edit]

References[edit]

  1. ^ Siev, M., Weinberg, R. and Penman, S. (1969). "The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin". J. Cell Biol. 41 (2): 510–520. doi:10.1083/jcb.41.2.510. PMC 2107749. PMID 5783871. 
  2. ^ Kondrashov A, Meijer HA, Barthet-Barateig A, Parker HN, Khurshid A, Tessier S et al. (2012). "Inhibition of polyadenylation reduces inflammatory gene induction". RNA 18 (12): 2236–50. doi:10.1261/rna.032391.112. PMC 3504674. PMID 23118416.