Orr became involved in Children's Theatre beginning at the age of 10 and started to develop her repetroire of voices. By the age of 14 was working at the CBC, as well as the Montreal Repertory Theatre and the Montreal Mountain Playhouse. She acted alongside such notables as Barry Morse (The Fugitive, Space: 1999), Christopher Plummer (The Sound of Music), and William Shatner (Star Trek).
With her solid background on the stage, Orr was hired for roles on CBC radio in such dramas as Laura Limited, and then moved to CBC television to portray the character of Suzie Mouse on the children's soap opera Chez Helene, a bilingual program devoted to teaching children English and French. In New York, Corinne began working regularly on radio, television, and as a voice artist. One of her first jobs was a continuing role on the daytime soap opera The Nurses. She also began her lucrative career as spokesperson for a variety of companies in a wide range of radio and television commercials. In addition, she dubbed foreign films into English.
Orr's animation credits include Star Blazers (Nova; third season), Ultraman, The Adventures of the Galaxy Rangers (as The Queen of the Crown), and Marine Boy, voicing the characters of Marine Boy, Neptina, and Cli-Cli. She also voiced characters in the classic Speed Racer series, in which she portrayed Spritle, Trixie, and all of the other female characters; as well in the Princess Gwenevere and the Jewel Riders series, where she voiced the main villain Lady Kale.
In addition to commercials and cartoons, Orr has narrated children's stories, provided voices for several dolls, and recorded numerous books on tape. For 18 years, she judged the Daytime Emmys. She was the voice of Snuggle the Bear in Snuggle's fabric softener commercials, and continues to work in such series as the Disney shows PB&J Otter and Stanley. She also read Aliki's Mummies Made in Egypt as its narrator for the PBS series Reading Rainbow on March 30, 1989 at the Boston Museum of Fine Arts. In the 2006 direct-to-DVD movie Spider's Web: A Pig's Tale, she voiced Walt, Ester, Cynthia and Lucy.
Corinne Orr was a Guest of Honor at the 2007 New York Anime Festival, and her voice can be heard in the 2008 Speed Racer movie (as Grand Prix female announcer). As of 2010, she is now the last surviving English-language cast member of Speed Racer.