Coronaridine

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Coronaridine
Coronaridine2.png
Systematic (IUPAC) name
Ibogamine-18-carboxylic acid methyl ester
Clinical data
Legal status ?
Identifiers
CAS number 467-77-6
ATC code None
PubChem CID 73489
ChemSpider 66179
ChEMBL CHEMBL364613
Chemical data
Formula C21H26N2O2 
Mol. mass 338.44 g/mol

Coronaridine is an alkaloid found in Tabernanthe iboga and related species,including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.[1]

Coronaridine presistently reduces the self-administration of cocaine and morphine in rats.[2]

See also[edit]

References[edit]

  1. ^ Delorenzi JC, Freire-de-Lima L, Gattass CR, et al. (July 2002). "In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis". Antimicrobial Agents and Chemotherapy 46 (7): 2111–5. doi:10.1128/aac.46.7.2111-2115.2002. PMC 127312. PMID 12069962. 
  2. ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.