Corticorelin

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Corticorelin
Corticorelin.png
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 79804-71-0
ATC code V04CD04
PubChem CID 16132344
UNII 305OE8862Y YesY
Chemical data
Formula C205H339N59O63S 
Mol. mass 4670.31 g/mol
 YesY (what is this?)  (verify)

Corticorelin is a diagnostic agent. It is a corticotropin-releasing hormone.[1]

The corticorelin stimulation test helps to differentiate between the etiologies of ACTH-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

  • If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
  • If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of Ectopic ACTH syndrome is confirmed.

See also[edit]

References[edit]

  1. ^ Andoh K, Kimura T, Saeki I, et al (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung 44 (6): 715–26. PMID 8053970.