Corticotropin-releasing hormone receptor

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corticotropin releasing hormone receptor 1
Symbol CRHR1
Alt. symbols CRHR
Entrez 1394
HUGO 2357
OMIM 122561
RefSeq XM_001128344
UniProt P34998
Other data
Locus Chr. 17 q12-q22
corticotropin releasing hormone receptor 2
Symbol CRHR2
Entrez 1395
HUGO 2358
OMIM 602034
RefSeq NM_001883
UniProt Q13324
Other data
Locus Chr. 7 p21-p15

Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH).[1] There are two receptors in the family, designated as type I and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).


CRHRs are important mediators in the stress response.[2] Cells in the anterior lobe of the pituitary gland known as corticotropes express the receptors and will secrete adrenocorticotropic hormone (ACTH) when stimulated.[3]


  1. ^ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. 
  2. ^ Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi:10.1016/S1043-2760(02)00670-7. PMID 12431840. 
  3. ^ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. doi:10.1159/000124513. PMID 3012395. 

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