Corticotropin-releasing hormone receptor

corticotropin releasing hormone receptor 2
Identifiers
Symbol	CRHR2
Entrez	1395
HUGO	2358
OMIM	602034
RefSeq	NM_001883
UniProt	Q13324
Other data
Locus	Chr. 7 p21-p15

corticotropin releasing hormone receptor 1
Identifiers
Symbol	CRHR1
Alt. symbols	CRHR
Entrez	1394
HUGO	2357
OMIM	122561
RefSeq	XM_001128344
UniProt	P34998
Other data
Locus	Chr. 17 q12-q22

From Wikipedia, the free encyclopedia

(Redirected from Corticotropin releasing hormone receptor)

Jump to: navigation, search

Corticotropin-releasing hormone receptors (CRHRs), also known known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH).^[1] There are two receptors in the family, designated as type I and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).

[edit] Function

CRHRs are important mediators in the stress response.^[2] Cells in the anterior lobe of the pituitary gland known as corticotropes express the receptors and will secrete adrenocorticotropic hormone (ACTH) when stimulated.^[3]

[edit] References

^ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.
^ Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi:10.1016/S1043-2760(02)00670-7. PMID 12431840.
^ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. doi:10.1159/000124513. PMID 3012395.

[edit] External links

"Corticotropin-Releasing Factor Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1321.
MeSH Corticotropin-releasing+hormone+receptors

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

This cell biology article is a stub. You can help Wikipedia by expanding it.

[pmid12615952-0] Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.

[pmid12431840-1] Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi:10.1016/S1043-2760(02)00670-7. PMID 12431840.

[pmid3012395-2] Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. doi:10.1159/000124513. PMID 3012395.

[1]

[2]

[3]

Corticotropin-releasing hormone receptor

[edit] Function

[edit] References

[edit] External links

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export

Languages