|Born||Corwin Herman Hansch
October 6, 1918
Kenmare, North Dakota
|Died||May 8, 2011
|Alma mater||University of Illinois
New York University
|Spouse||Gloria J. Hansch (nee Tomasulo) (m.1945?–2011) (his death) (1 child)|
Early life and childhood
Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.
Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.
He is also noted for the Hansch equation, which is used in
- Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
- Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
- Hansch-Fujita constant - The Hansch-Fujita constant describes the contribution of a substituent to the lipophilicity of a compound.
Research Interests: Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).
- Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)
- Book: Exploring QSAR - Corwin Hansch, Albert Leo and David Hoekman
- Reviews: 23 Reviews
- Journal articles: Co-authored more than 265 articles
His research group at Pomona College worked on QSAR studies and in building and expanding the database of chemical and physical data as C-QSAR and Bioloom. His postgraduate associates were Rajni Garg, Cynthia D Selassie, Suresh Babu Mekapati, and Alka Kurup.
- Example for Hansch equation and Hansch-Fujita constant
- Pomona College homepage
- Biography, The QSAR and Modelling Society News, October 1998
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