Corwin Hansch
| Corwin Hansch | |
|---|---|
| Born | Corwin Herman Hansch October 6, 1918 Kenmare, North Dakota |
| Died | May 8, 2011 (aged 92) Claremont, California |
| Nationality | American |
| Fields | Organic Chemistry |
| Institutions | Pomona College Manhattan Project |
| Alma mater | University of Illinois New York University |
| Spouse | Gloria J. Hansch (nee Tomasulo) (m.1945?–2011) (his death) (1 child) |
Corwin Herman Hansch (October 6, 1918 – May 8, 2011[1]) was a Professor of Chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'
Contents |
[edit] Early life and childhood
He was born on October 6, 1918 in Kenmare, North Dakota.
[edit] Education
He earned a B.S. from the University of Illinois in 1940 and a Ph.D. from New York University in 1944.
[edit] Career
Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.
Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.
He is also noted for the Hansch equation, which is used in
- Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
- Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
- Hansch-Fujita π constant - The Hansch-Fujita π constant describes the contribution of a substituent to the lipophilicity of a compound.
Research Interests: Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).
- Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)
[edit] Death
He died of pneumonia on May 8, 2011 in Claremont, California at 92.[2]
[edit] See also
[edit] Notes
- Book: Exploring QSAR - Corwin Hansch, Albert Leo and David Hoekman
- Reviews: 23 Reviews[3]
- Journal articles: Co-authored more than 265 articles
His research group at Pomona College worked on QSAR studies and in building and expanding the database of chemical and physical data as C-QSAR and Bioloom. His postgraduate associates were Rajni Garg, Cynthia D Selassie, Suresh Babu Mekapati, and Alka Kurup.
[edit] References
[edit] External links
- Example for Hansch equation and Hansch-Fujita π constant
- Pomona College homepage
- Biography, The QSAR and Modelling Society News, October 1998
   |
This biographical article about an American chemist is a stub. You can help Wikipedia by expanding it. |
