Coumatetralyl

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Coumatetralyl
Coumatetralyl.svg
Names
IUPAC name
(RS)-2-Hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-4H-chromen-4-one
Identifiers
5836-29-3 YesY
ChemSpider 10468736 YesY
Jmol-3D images Image
KEGG C16806 YesY
PubChem 22095
Properties
C19H16O3
Molar mass 292.33 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. Symptoms of overexposure relate to failure of the blood clotting mechanism and include bleeding gums and failure of blood clotting after skin wounds. After one exposure the toxicity of coumatetralyl is relatively low, however if overexposure continues for several days the product becomes more toxic. The product must therefore be constantly present in the bloodstream for more than 1 to 2 days in order to be highly toxic. A single exposure, even though relatively large, may not produce toxic symptoms as the compound is quite rapidly metabolised. Chronic animal studies show no evidence of carcinogenic or teratogenic effects.

Common applications[edit]

Coumatetralyl is commonly used with grains and other cereals as a rodent poison in conjunction with a tracking powder to monitor feeding activity in a particular area. Tracking powder also clings to fur, which allows more poison to be ingested from grooming. Concentrations of the chemical are usually 500 mg per 1 kg of bait.

Rat poison grains

Treatment[edit]

Vitamin K1 (phylloquinone) is antidotal.