County Route 161 is an east–west route in the town of Lancaster. CR 161 begins at its west end at Transit Road (NY 78) and travels through the town of Lancaster, north of the village of Depew. An important intersection along its route consists of the intersection of Central Avenue (CR 57) and Harris Hill Road (CR 276) roughly 1 mile (1.6 km) east of Transit Road. After this intersection, Pleasant View Drive travels through the less densely populated part of town until it comes to its east end at Pavement Road (CR 139).
County Route 162 is an east–west route in the town of Hamburg named Sowles Road. CR 162 begins at an intersection with Camp Road (NY 75). As this route heads east, it intersects Southwestern Boulevard (US 20) just two-tenths of a mile into the route. CR 162 then heads east through the town passing under I-90 and continuing to another major intersection with South Park Avenue (US 62). After that intersection, Sowles Road heads to its east end at the intersection of Sowles Road, McKinley Parkway (CR 204), and Bayview Road (CR 169).
County Route 163 is an east–west route in the town of Clarence, town of Newstead, and village of Akron. CR 163 begins at Salt Road (CR 560), its west end, and travels east into the town of Newstead and into village of Akron to its east end at the intersection of Buell Street (NY 93) and Parkview Drive (CR 167).
County Route 164 is a short north–south route in the town of Lancaster. CR 164 begins at an intersection with William Street (CR 338) in the town of Lancaster. This route then heads north as Lake Avenue toward the village of Lancaster, where it ends at the village Line.
County Route 165 is an east–west route in the town of Cheektowaga. It is named Cayuga Creek Road as the highway roughly parallels Cayuga Creek. CR 165 begins at Harlem Road (NY 240) and heads east–northeast in overall direction to its east end at William Street (CR 270).
County Route 166 is an east–west route in the town of Alden named North Road. CR 166 begins at an intersection with Sandridge and Wende roads (CR 113). The route then heads east, and has an intersection with Crittenden Road (CR 1). CR 166 then continues east into Genesee County where the road then becomes Summer Road and CR 21.
County Route 167 is a north–south route in the village of Akron. Parkview Drive has its south (or west) end at the intersection of Buell Street (NY 93) and Clarence Center Road (CR 163). Parkview Drive then heads east into Akron Falls Park and curves to the north, over Murder Creek. After crossing the creek, Parkview intersects East Avenue and shortly after comes to its north end at Main Street in the village of Akron.
County Route 169 begins at an intersection with Abbott Road (CR 4), Armor–Duells Road (CR 44), and Clark Street (CR 51) in a hamlet of Hamburg named Armor. CR 169 (Bayview Road) heads north (northwest) through the town of Hamburg towards its north end at its intersection with McKinley Parkway (CR 204) and Sowles Road (CR 162). The portion of Bayview Road located west of South Park Avenue (US 62) in Hamburg is numbered CR 575.
County Route 170, named Sawyer Avenue, is an east–west route in the town of Tonawanda. CR 170 begins at River Road (NY 266) which is its west end. The road then heads east intersecting only local roads that serve the industrial section of Tonawanda. CR 170 ends at its eastern terminus at the intersection of Kenmore Avenue (CR 189) and I-190's southbound exit onto Kenmore Avenue.
County Route 171 is a north–south route named Sweet Home Road in the town of Amherst. CR 171 begins at its south end at Eggert Road (CR 130) near the community of Eggertsville in Amherst. CR 171 then heads north and intersects Sheridan Drive (NY 324) a major thoroughfare through Buffalo's north suburbs. CR 171 continues north through a residential area and takes northeast direction and then north direction to its north end at Maple Road (CR 192). Sweet Home Road continues north of the intersection as NY 952T, an unsigned reference route.
Sweet Home Road is designated as CR 171 from CR 130 to CR 192, NY 952T from CR 192 to CR 232, and CR 301 from CR 232 to CR 2.
County Route 172, named Hemstreet Road, is a north–south road in the towns of Elma and Marilla. It begins at an intersection with East Aurora – Porterville Road (CR 6). CR 172 travels northwest, intersecting a handful of local streets before arriving at its north end at an intersection with Jamison Road (CR 574) and Creek Road (CR 334).
County Route 173 is an east–west route in the town of Amherst. CR 173 begins at its west end at North Forest Road (CR 294). Heim Road only has intersections with local roads for its entire length. CR 173 comes to its east end at Dodge Road (CR 45).
County Route 174 is an east–west route in a section of the town of Eden named Eden Valley. CR 174's west end is at an intersection with Gowanda State Road (US 62) and Bley Road (CR 474). CR 174 only travels nine-tenths of mile to its east end at Sisson Highway (NY 75).
County Route 175 is an east–west route in the town of Wales named Centerline Road. CR 175 begins at an intersection with Blakeley Corners Road (CR 85) and Reiter Road (CR 383). From there CR 175 heads east intersecting local roads, and Strykersville Road (NY 78) before traveling a little further east to the route's end at the Wyoming County line.
County Route 177 is an east–west route in the town of Orchard Park. CR 177's west end (north end) is at Southwestern Boulevard (US 20). From there, CR 177 heads southeast, named Taylor Road, and parallels the Buffalo and Pittsburgh Railroad and passes under the Southern Expressway (US 219). Just after CR 177 turns left and heads east on New Taylor Road, and intersects local roads until coming to an end at North Buffalo Road (NY 240/NY 277) just inside the village of Orchard Park.
County Route 181 is a north–south route in the town of Concord. CR 181 begins at its intersection with Buffalo Road (CR 413) and North Street (CR 412) at the Springville village line with Concord. CR 181 heads north through the town of Concord intersecting well-traveled Genesee Road (CR 49), and then heads north to its north end at Springville–Boston Road (CR 228).
County Route 183 is a north–south route in the town of Evans. CR 183 begins at its south end at Bennett Road (CR 96), and only travels just under a mile to its north end with Lake Shore Road (CR 111 from the south; CR 127 from the north).
County Route 186, named New Road, is a well-traveled north–south route in the northeast part of Amherst. CR 186's south end is at Dodge Road (CR 45, formerly part of NY 356). The route travels north from there only intersecting local town roads until it reaches Smith Road (CR 297) at a red blinking light four-way stop. Just north of that intersection, New Road has an intersection with Millersport Highway (NY 263). This is a major north–south highway in the town of Amherst and is a major route for traffic from Buffalo to Lockport. After intersecting Millersport Highway, Route 186 travels north through a sparsely populated area of Amherst. Just before Route 186's northern terminus it intersects Tonawanda Creek Road (CR 2). At the southwest corner of this intersection lies the Amherst Museum. The northern terminus of Route 186 is at the Niagara County line, which is separated from Erie County by Tonawanda Creek. The roadway continues north into Niagara County as CR 130, named East Canal Road.
County Route 187 is an east–west route in the towns of Hamburg and West Seneca, as well as the southern border of the city of Lackawanna. CR 187 starts at the northern terminus of CR 204, or McKinley Parkway at the Hamburg–Lackawanna line. Here CR 187 is known as Willet Road and travels east towards Abbott Road. After crossing Abbott, Route 187 changes names and becomes Berg Road. CR 187 then travels into the town of West Seneca as it travels east and passes under the Southern Expressway (US 219) on its way to its eastern terminus at Orchard Park Road (NY 240) in West Seneca.
County Route 189, named Kenmore Avenue, is a roughly east–west route in the town of Tonawanda and city of Buffalo. CR 189 begins at an intersection with Grand Island Boulevard (NY 950C and formerly part of NY 324). At the west end, Kenmore Avenue has a north–south direction, so just south of its west end is an intersection with I-190 and CR 117 (Sawyer Avenue). CR 189 overlaps NY 324 north of I-190's southbound ramp. CR 189 turns southeast and passes under I-190 as it heads east and intersects Sheridan Drive (NY 325). After Route 189's intersection with Sheridan, it passes General Motors' Powertrain Plant located in Tonawanda, and then has intersections with local Buffalo streets as it enters the city and comes to an end at CR 550 in Buffalo.
Kenmore Avenue is numbered as three separate county routes along its path: CR 189; CR 550 in the city of Buffalo from the Tonawanda town line to Military Road (NY 265); and CR 307 from Military Road (NY 265) in Buffalo to Main Street (NY 5) at the Amherst–Buffalo line.
County Route 192 is approximately a 3-mile (4.8 km) long east–west route in the town of Amherst, a northeast suburb of Buffalo. The road is named Maple Road and located entirely in Amherst. CR 192 begins at an intersection with CR 196 (Brighton Road) and US 62 (Niagara Falls Boulevard) at the Amherst–Tonawanda town line, (CR 192 West end). The road travels east from there intersecting CR 171 and NY 952T (Sweet Home Road), NY 263 (Millersport Highway), CR 294 (North Forest Road), CR 87 (Hopkins Road), then to its east end at an intersection with NY 78 (Transit Road) and CR 37 (Greiner Road) at the Amherst–Clarence town line.