This was Whitten's last album release before his death from a drug overdose in 1972. For the recording of this album in the fall of 1970, they also recruited Ry Cooder, who had worked previously with Nitzsche on sessions for the Stones. Cooder plays on three tracks.
A live version of "Downtown" by Whitten and Young would appear on Young's 1975 album Tonight's the Night, entitled "(Come On Baby Let's Go) Downtown." On Neil Young's 2007 vault release Live at the Fillmore East 1970, the song is credited to Whitten alone.
Crazy Horse was released on compact disc on March 22, 1994, as part of the Warner Brothers archive series, produced for compact disc by Lee Herschberg. It appeared in its entirety as part of Rhino Handmade'sScratchy compilation from 2005, which also included outtakes from the sessions for this album. That compilation is no longer in print.