On 19 November 2011, MRT internally appointed Kaliopi as the representative for Macedonia at the Eurovision Song Contest 2012. After this announcement, Kaliopi and MRT held a press conference where Kaliopi revealed that she was unsure about what type of song she would take to the competition, but that she would consider her own compositions as well as those of her colleagues and international submissions. The instrumental composition for Crno i belo was sent to Kaliopi by former band member and ex-husband Romeo Gril, with whom she had extensively collaborated with previously on solo material, as well as decades prior when the band "Kaliopi" was still active. Kaliopi wrote lyrics for the composition and proceeded with recording the song in early 2012 with Gril at the MRT studio in Skopje.
On 29 February, in an hour and a half long program aired by MRT, Kaliopi was joined by musical guests from the region where she performed songs from her repertoire, as well as unveiling Crno i belo for the first time. In the same evening Kaliopi also performed the English version of the song, Black and White.
Macedonia was drawn to compete 2nd at the second semi-finals on 24 May. The song eventually advanced into the finals and was drawn to perform 22nd in the line-up. At the grand final, held on 26 May, the song eventually placed 12th with a total of 71 points, ex aequo with Mandinga (band) (Romania). This was Macedonia's best placing since their entry in the 2007 contest.
The music video for "Crno i belo", directed by Aleksandar Ristovski - Princ, was filmed in Bitola. The video premiered on 17 March 2012. It is set in an empty theatre and abandoned building. Kaliopi performs the song with a piano on stage while supporting musicians are filmed at other locations. The video was submitted as the official preview video for Macedonia in the Eurovision Song Contest.