The Cueva were an indigenous people that lived in the Darién region of eastern Panama. They were completely exterminated between 1510 and 1535 due to the effects of Spanish colonization. Following the massacre of the Cueve, the island of Isla Chuche was populated by African slaves, imported there by the Spaniards to search for pearls.
The Darién region formerly occupied by the Cueva became populated by the Kuna after their westward expansion during the 17th and 18th centuries.
- Whitehead, Neil L. (1999). The crises and transformations of invaded societies: The Caribbean (1492–1580). In F. Salomon & S. B. Schwartz (Eds.), The Cambridge history of the native peoples of South America: South America (Vol. 3, Pt. 1, pp. 864–903). Cambridge: Cambridge University Press.
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