Cunninghamella

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Cunninghamella
Cunninghamella echinulata01.jpg
Cunninghamella echinulata
Scientific classification e
Kingdom: Fungi
Order: Mucorales
Family: Cunninghamellaceae
Genus: Cunninghamella
Matruchot, 1903
Type species
Cunninghamella africana
Matr. (1903)

Cunninghamella is a genus of fungus in the Mucorales order, and the family Cunninghamellaceae.[1]

It can grow on Sabouraud's agar.[2]

Species[edit]

The genus Cunninghamella contains 16 species:[3]

Synonyms for other species[edit]

Use in the investigation of drug and xenobiotics metabolism[edit]

Members of this genus are often used in studies investigating the metabolism of drugs, because these species metabolize a wide range of drugs in manners similar to mammalian enzyme systems.[4] Many species are also capable of oxidizing polycyclic aromatic hydrocarbons, a class of stable organic molecules that tends to persist in the environment and contains many known carcinogenic and mutagenic compounds.[5]

The presence of a cytochrome P-450 has been demonstrated in C. bainieri.[6]

See also[edit]

References[edit]

  1. ^ Cunninghamella at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ "Mycology Online -- Cunninghamella". Retrieved 2008-12-10. 
  3. ^ "Cunninghamella". Retrieved 2009-03-17. 
  4. ^ Asha S, Vidyavathi M (2009). "Cunninghamella--a microbial model for drug metabolism studies--a review". Biotechnol. Adv. 27 (1): 16–29. doi:10.1016/j.biotechadv.2008.07.005. PMID 18775773. Retrieved 2009-03-17. 
  5. ^ Cerniglia, Carl E. (1992). "Biodegradation of polycyclic aromatic hydrocarbons". Biodegradation 3 (2–3): 351–368. doi:10.1007/BF00129093. 
  6. ^ Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: Evidence for the presence of cytochrome P-450. J.P. Ferris, L.H. MacDonald, M.A. Patrie and M.A. Martin, Archives of Biochemistry and Biophysics, Volume 175, Issue 2, August 1976, pages 443-452, doi:10.1016/0003-9861(76)90532-4

External links[edit]