He ran his own club in London from 1951 and headed a seven-member ensemble; sidemen in this group included Chris Barber, Alan Elsdon, Al Fairweather, and Colin Smith. Cy Laurie's Club was first in Ham Yard and went on to become the famous Mod club The Scene in the 1960s. From the mid-fifties he also had regular appearances at a basement club in Great Windmill Street, below a porn cinema and opposite the Windmill Club
He quit music from 1960 to 1968, but returned to lead another ensemble at the end of the decade. His career saw a resurgence late in the 1970s; he toured in ensembles as a soloist and sometimes led his own groups. He played with Eggy Ley and Max Collie in the 1980s. He continued performing into the 1990s.