Cyanocobalamin reductase (cyanide-eliminating)

Cyanocobalamin reductase (cyanide-eliminating)
Identifiers
EC number	1.16.1.6
CAS number	131145-00-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles

In enzymology, a cyanocobalamin reductase (cyanide-eliminating) (EC 1.16.1.6) is an enzyme that catalyzes the chemical reaction

cob(I)alamin + cyanide + NADP⁺ $\rightleftharpoons$ cyanocob(III)alamin + NADPH + H⁺

The 3 substrates of this enzyme are cob(I)alamin, cyanide, and NADP⁺, whereas its 3 products are cyanocob(III)alamin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(I)alamin, cyanide:NADP+ oxidoreductase. Other names in common use include cyanocobalamin reductase, cyanocobalamin reductase (NADPH, cyanide-eliminating), cyanocobalamin reductase (NADPH, CN-eliminating), and NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating). This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

References

• Watanabe F, Oki Y, Nakano Y, Kitaoka S (Tokyo). "Occurrence and characterization of cyanocobalamin reductase (NADPH CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis". J. Nutr. Sci. Vitaminol. (1): 1–10. PMID 3134526.