Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia that tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.
It is often present among several members of the same family. Treatment includes G-CSF and usually improves after puberty.
Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.
See also 
May be associated with oral cankers, canker sores or lesions. McBride DR (July 2000). "Management of aphthous ulcers". Am Fam Physician 62 (1): 149–54, 160. PMID 10905785.
External links