Cyclic neutropenia
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| Cyclic neutropenia | |
|---|---|
| Classification and external resources | |
| ICD-9 | 288.02 |
| OMIM | 162800 |
| DiseasesDB | 30103 |
Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia that tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.[1]:811
It is often present among several members of the same family. Treatment includes G-CSF and usually improves after puberty.
Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.[2]
[edit] See also
May be associated with oral cankers, canker sores or lesions. http://www.aafp.org/afp/20000701/149.html
[edit] External links
[edit] References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Sera Y, Kawaguchi H, Nakamura K, et al. (2005). "A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia". Haematologica 90 (8): 1032–1041. PMID 16079102. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=16079102.
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