Cyclin B2

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Cyclin B2
Identifiers
Symbols CCNB2 ; HsT17299
External IDs OMIM602755 MGI88311 HomoloGene74359 ChEMBL: 3723 GeneCards: CCNB2 Gene
RNA expression pattern
PBB GE CCNB2 202705 at tn.png
PBB GE CCNB2 gnf1h06136 s at tn.png
PBB GE CCNB2 gnf1h06137 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9133 12442
Ensembl ENSG00000157456 ENSMUSG00000032218
UniProt O95067 P30276
RefSeq (mRNA) NM_004701 NM_007630
RefSeq (protein) NP_004692 NP_031656
Location (UCSC) Chr 15:
59.4 – 59.42 Mb
Chr 9:
70.41 – 70.42 Mb
PubMed search [1] [2]

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[1]

See also[edit]

Interactions[edit]

Cyclin B2 has been shown to interact with TGF beta receptor 2.[2]

References[edit]

  1. ^ "Entrez Gene: CCNB2 cyclin B2". 
  2. ^ Liu, J H; Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269–75. doi:10.1038/sj.onc.1202263. ISSN 0950-9232. PMID 9926943. 

Further reading[edit]