G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Hirai H, Roussel MF, Kato JY, et al. (1995). "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.". Mol. Cell. Biol.15 (5): 2672–81. PMC230497. PMID7739547.
Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner.". Mol. Cell. Biol.14 (3): 2077–86. PMC358568. PMID8114739.
Palmero I, Holder A, Sinclair AJ, et al. (1993). "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.". Oncogene8 (4): 1049–54. PMID8455931.
Brooks AR, Shiffman D, Chan CS, et al. (1996). "Functional analysis of the human cyclin D2 and cyclin D3 promoters.". J. Biol. Chem.271 (15): 9090–9. doi:10.1074/jbc.271.15.9090. PMID8621559.
Hirai H, Sherr CJ (1996). "Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1.". Mol. Cell. Biol.16 (11): 6457–67. PMC231647. PMID8887674.
Sicinski P, Donaher JL, Geng Y, et al. (1997). "Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.". Nature384 (6608): 470–4. doi:10.1038/384470a0. PMID8945475.
Kitagawa M, Higashi H, Jung HK, et al. (1997). "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.". EMBO J.15 (24): 7060–9. PMC452531. PMID9003781.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Gómez Lahoz E, Liegeois NJ, Zhang P, et al. (1999). "Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.". Mol. Cell. Biol.19 (1): 353–63. PMC83893. PMID9858559.
Sansal I, Dupont E, Toru D, et al. (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.". Oncogene19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID11042687.
Choi D, Lee EY, Yoon S, et al. (2001). "Clinical correlation of cyclin D2 mRNA expression in human luteinized granulosa cells.". J. Assist. Reprod. Genet.17 (10): 574–9. doi:10.1023/A:1026470825514. PMID11209538.
Tanguay DA, Colarusso TP, Doughty C, et al. (2001). "Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets.". J. Immunol.166 (7): 4273–7. PMID11254678.
Choi D, Yoon S, Lee E, et al. (2001). "The expression of pseudogene cyclin D2 mRNA in the human ovary may be a novel marker for decreased ovarian function associated with the aging process.". J. Assist. Reprod. Genet.18 (2): 110–3. doi:10.1023/A:1026538826392. PMID11285977.