G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Sicinski P, Donaher JL, Geng Y, et al. (1997). "Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.". Nature384 (6608): 470–4. doi:10.1038/384470a0. PMID8945475.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Sansal I, Dupont E, Toru D, et al. (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.". Oncogene19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID11042687.
Tanguay DA, Colarusso TP, Doughty C, et al. (2001). "Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets.". J. Immunol.166 (7): 4273–7. doi:10.4049/jimmunol.166.7.4273. PMID11254678.