Cyclin E1

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Cyclin E1
Protein CCNE1 PDB 1w98.png
PDB rendering based on 1w98.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCNE1 ; CCNE
External IDs OMIM123837 MGI88316 HomoloGene14452 ChEMBL: 3617 GeneCards: CCNE1 Gene
RNA expression pattern
PBB GE CCNE1 213523 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 898 12447
Ensembl ENSG00000105173 ENSMUSG00000002068
UniProt P24864 Q61457
RefSeq (mRNA) NM_001238 NM_007633
RefSeq (protein) NP_001229 NP_031659
Location (UCSC) Chr 19:
30.3 – 30.32 Mb
Chr 7:
38.1 – 38.11 Mb
PubMed search [1] [2]

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.[1]

Function[edit]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.[2]

See also[edit]

Interactions[edit]

Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2,[3][4] Cdk1,[3][5] CDC25A,[3][6] Cyclin-dependent kinase 2,[3][5][7][8][9][10] SMARCA4,[3][11] CDKN1B,[3][9] HERC5,[12] CUL3[13] and P21.[7]

References[edit]

  1. ^ Lew DJ, Dulic V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. 
  2. ^ "Entrez Gene: CCNE1 cyclin E1". 
  3. ^ a b c d e f Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMC 116074. PMID 9891079. 
  4. ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383. 
  5. ^ a b Koff, A; Giordano A; Desai D; Yamashita K; Harper J W; Elledge S; Nishimoto T; Morgan D O; Franza B R; Roberts J M (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science (UNITED STATES) 257 (5077): 1689–94. doi:10.1126/science.1388288. ISSN 0036-8075. PMID 1388288. 
  6. ^ Xu, X; Burke S P (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. (UNITED STATES) 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. ISSN 0021-9258. PMID 8617791. 
  7. ^ a b McKenzie, Pamela P; Danks Mary K; Kriwacki Richard W; Harris Linda C (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. (United States) 63 (13): 3840–4. ISSN 0008-5472. PMID 12839982. 
  8. ^ Mayer, Christine; Zhao Jian; Yuan Xuejun; Grummt Ingrid (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. (United States) 18 (4): 423–34. doi:10.1101/gad.285504. ISSN 0890-9369. PMC 359396. PMID 15004009. 
  9. ^ a b Connor, Michael K; Kotchetkov Rouslan; Cariou Sandrine; Resch Ansgar; Lupetti Rafaella; Beniston Richard G; Melchior Frauke; Hengst Ludger; Slingerland Joyce M (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell (United States) 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. ISSN 1059-1524. PMC 140238. PMID 12529437. 
  10. ^ Boudrez, A; Beullens M; Groenen P; Van Eynde A; Vulsteke V; Jagiello I; Murray M; Krainer A R; Stalmans W; Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. (UNITED STATES) 275 (33): 25411–7. doi:10.1074/jbc.M001676200. ISSN 0021-9258. PMID 10827081. 
  11. ^ Wong, A K; Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland A M, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian S V, Teng D H, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. (UNITED STATES) 60 (21): 6171–7. ISSN 0008-5472. PMID 11085541. 
  12. ^ Mitsui, K; Nakanishi M; Ohtsuka S; Norwood T H; Okabayashi K; Miyamoto C; Tanaka K; Yoshimura A; Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. (UNITED STATES) 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. ISSN 0006-291X. PMID 10581175. 
  13. ^ Singer, J D; Gurian-West M; Clurman B; Roberts J M (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. (UNITED STATES) 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. ISSN 0890-9369. PMC 317026. PMID 10500095. 

Further reading[edit]