The protein encoded by this gene belongs to the highly conservedcyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
^ abKoff A, Giordano A, Desai D, Yamashita K, Harper J, Elledge S et al. (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science257 (5077): 1689–94. PMID1388288.
^ abMcKenzie P, Danks M, Kriwacki R, Harris L (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res.63 (13): 3840–4. PMID12839982.
^Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I et al. (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem.275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID10827081.
^Mitsui K, Nakanishi M, Ohtsuka S, Norwood T, Okabayashi K, Miyamoto C et al. (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun.266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID10581175.
^Li Y, Graham C, Lacy S, Duncan A, Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev.7 (12A): 2366–77. PMID8253383.
^Wong A, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K et al. (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res.60 (21): 6171–7. PMID11085541.
Hinds P, Mittnacht S, Dulic V, Arnold A, Reed S, Weinberg R (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.". Cell70 (6): 993–1006. doi:10.1016/0092-8674(92)90249-C. PMID1388095.
Koff A, Giordano A, Desai D, Yamashita K, Harper J, Elledge S et al. (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.". Science257 (5077): 1689–94. doi:10.1126/science.1388288. PMID1388288.
Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M et al. (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.". Cell66 (6): 1217–28. doi:10.1016/0092-8674(91)90044-Y. PMID1833068.
Demetrick D, Matsumoto S, Hannon G, Okamoto K, Xiong Y, Zhang H et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).". Cytogenet. Cell Genet.69 (3-4): 190–2. doi:10.1159/000133960. PMID7698009.
Li Y, Graham C, Lacy S, Duncan A, Whyte P (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev.7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID8253383.
Xu X, Burke S (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25.". J. Biol. Chem.271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID8617791.
Geng Y, Eaton E, Picón M, Roberts J, Lundberg A, Gifford A et al. (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.". Oncogene12 (6): 1173–80. PMID8649818.
Poon R, Jiang W, Toyoshima H, Hunter T (1996). "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.". J. Biol. Chem.271 (22): 13283–91. doi:10.1074/jbc.271.22.13283. PMID8662825.
Li H, Lahti J, Valentine M, Saito M, Reed S, Look A et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.". Genomics32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID8833152.