Cyclin H

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Cyclin H
Protein CCNH PDB 1jkw.png
PDB rendering based on 1jkw.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCNH ; CAK; CycH; p34; p37
External IDs OMIM601953 MGI1913921 HomoloGene946 ChEMBL: 2165 GeneCards: CCNH Gene
RNA expression pattern
PBB GE CCNH 204093 at tn.png
More reference expression data
Species Human Mouse
Entrez 902 66671
Ensembl ENSG00000134480 ENSMUSG00000021548
UniProt P51946 Q61458
RefSeq (mRNA) NM_001199189 NM_023243
RefSeq (protein) NP_001186118 NP_075732
Location (UCSC) Chr 5:
86.69 – 86.71 Mb
Chr 13:
85.19 – 85.22 Mb
PubMed search [1] [2]

Cyclin-H is a protein that in humans is encoded by the CCNH gene.[1][2]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.[2]


Cyclin H has been shown to interact with P53,[3] Cyclin-dependent kinase 7[4][5][6] and MNAT1.[7][8]


  1. ^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303. 
  2. ^ a b "Entrez Gene: CCNH cyclin H". 
  3. ^ Schneider, E; Montenarh M; Wagner P (November 1998). "Regulation of CAK kinase activity by p53". Oncogene (ENGLAND) 17 (21): 2733–41. doi:10.1038/sj.onc.1202504. ISSN 0950-9232. PMID 9840937. 
  4. ^ Mäkelä, T P; Tassan J P; Nigg E A; Frutiger S; Hughes G J; Weinberg R A (September 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature (ENGLAND) 371 (6494): 254–7. doi:10.1038/371254a0. ISSN 0028-0836. PMID 8078587. 
  5. ^ Yee, A; Nichols M A; Wu L; Hall F L; Kobayashi R; Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393. 
  6. ^ Garber, M E; Mayall T P; Suess E M; Meisenhelder J; Thompson N E; Jones K A (September 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6958–69. doi:10.1128/MCB.20.18.6958-6969.2000. ISSN 0270-7306. PMC 88771. PMID 10958691. 
  7. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  8. ^ Talukder, Amjad H; Mishra Sandip K; Mandal Mahitosh; Balasenthil Seetharaman; Mehta Sonal; Sahin Aysegul A; Barnes Christopher J; Kumar Rakesh (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. (United States) 278 (13): 11676–85. doi:10.1074/jbc.M209570200. ISSN 0021-9258. PMID 12527756. 

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