Cyclin H

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Cyclin H
Protein CCNH PDB 1jkw.png
PDB rendering based on 1jkw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCNH ; CAK; CycH; p34; p37
External IDs OMIM601953 MGI1913921 HomoloGene946 ChEMBL: 2165 GeneCards: CCNH Gene
RNA expression pattern
PBB GE CCNH 204093 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 902 66671
Ensembl ENSG00000134480 ENSMUSG00000021548
UniProt P51946 Q61458
RefSeq (mRNA) NM_001199189 NM_023243
RefSeq (protein) NP_001186118 NP_075732
Location (UCSC) Chr 5:
86.69 – 86.71 Mb
Chr 13:
85.19 – 85.22 Mb
PubMed search [1] [2]

Cyclin-H is a protein that in humans is encoded by the CCNH gene.[1][2]

Function[edit]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.[2]

Interactions[edit]

Cyclin H has been shown to interact with P53,[3] Cyclin-dependent kinase 7[4][5][6] and MNAT1.[7][8]

References[edit]

  1. ^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y et al. (Jan 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303. 
  2. ^ a b "Entrez Gene: CCNH cyclin H". 
  3. ^ Schneider E, Montenarh M, Wagner P (Nov 1998). "Regulation of CAK kinase activity by p53". Oncogene 17 (21): 2733–41. doi:10.1038/sj.onc.1202504. PMID 9840937. 
  4. ^ Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587. 
  5. ^ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Research 55 (24): 6058–62. PMID 8521393. 
  6. ^ Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Molecular and Cellular Biology 20 (18): 6958–69. doi:10.1128/MCB.20.18.6958-6969.2000. PMC 88771. PMID 10958691. 
  7. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  8. ^ Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA et al. (Mar 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756. 


Further reading[edit]