The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
Cyclin K has been shown to interact with CDK9. Cyclin K also interacts with HIV nef protein. Khan SZ, Mitra D (Jul 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner". The Journal of Biological Chemistry286 (26): 22943–22954. doi:10.1074/jbc.M110.201194. PMID21555514.</ref>
^ abFu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID10574912.
Lin X, Taube R, Fujinaga K, Peterlin BM (May 2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". The Journal of Biological Chemistry277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID11884399.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.