Cyclin K

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Cyclin K
Protein CCNK PDB 2i53.png
PDB rendering based on 2i53.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCNK ; CPR4
External IDs OMIM603544 HomoloGene14748 GeneCards: CCNK Gene
RNA expression pattern
PBB GE CCNK 219273 at tn.png
More reference expression data
Species Human Mouse
Entrez 8812 12454
Ensembl ENSG00000090061 ENSMUSG00000021258
UniProt O75909 O88874
RefSeq (mRNA) NM_001099402 NM_009832
RefSeq (protein) NP_001092872 NP_033962
Location (UCSC) Chr 14:
99.95 – 100 Mb
Chr 12:
108.18 – 108.2 Mb
PubMed search [1] [2]

Cyclin-K is a protein that in humans is encoded by the CCNK gene.[1][2][3]


The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.[3]


Cyclin K has been shown to interact with CDK9.[2] Cyclin K also interacts with HIV nef protein. Khan SZ, Mitra D (Jul 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner". The Journal of Biological Chemistry 286 (26): 22943–22954. doi:10.1074/jbc.M110.201194. PMID 21555514. </ref>


  1. ^ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity". Molecular and Cellular Biology 18 (7): 4291–300. PMC 109013. PMID 9632813. 
  2. ^ a b Fu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912. 
  3. ^ a b "Entrez Gene: CCNK cyclin K". 

Further reading[edit]