Cyclin K

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Cyclin K
Protein CCNK PDB 2i53.png
PDB rendering based on 2i53.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCNK ; CPR4
External IDs OMIM603544 HomoloGene14748 GeneCards: CCNK Gene
RNA expression pattern
PBB GE CCNK 219273 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8812 12454
Ensembl ENSG00000090061 ENSMUSG00000021258
UniProt O75909 O88874
RefSeq (mRNA) NM_001099402 NM_009832
RefSeq (protein) NP_001092872 NP_033962
Location (UCSC) Chr 14:
99.95 – 100 Mb
Chr 12:
108.18 – 108.2 Mb
PubMed search [1] [2]

Cyclin-K is a protein that in humans is encoded by the CCNK gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.[3]

Interactions[edit]

Cyclin K has been shown to interact with CDK9.[2] Cyclin K also interacts with HIV nef protein. Khan SZ, Mitra D (Jul 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner". The Journal of Biological Chemistry 286 (26): 22943–22954. doi:10.1074/jbc.M110.201194. PMID 21555514. </ref>

References[edit]

  1. ^ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity". Molecular and Cellular Biology 18 (7): 4291–300. PMC 109013. PMID 9632813. 
  2. ^ a b Fu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912. 
  3. ^ a b "Entrez Gene: CCNK cyclin K". 

Further reading[edit]