Cyclin T2

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Cyclin T2
Protein CCNT2 PDB 2ivx.png
PDB rendering based on 2ivx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCNT2 ; CYCT2
External IDs OMIM603862 MGI1920199 HomoloGene14043 ChEMBL: 1293321 GeneCards: CCNT2 Gene
RNA expression pattern
PBB GE CCNT2 204645 at tn.png
PBB GE CCNT2 214638 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 905 72949
Ensembl ENSG00000082258 ENSMUSG00000026349
UniProt O60583 Q7TQK0
RefSeq (mRNA) NM_001241 NM_028399
RefSeq (protein) NP_001232 NP_082675
Location (UCSC) Chr 2:
135.68 – 135.72 Mb
Chr 1:
127.77 – 127.81 Mb
PubMed search [1] [2]

Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene.[1][2][3]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.[3]

Interactions[edit]

Cyclin T2 has been shown to interact with CDK9[1] and Retinoblastoma protein.[4]

References[edit]

  1. ^ a b Peng J, Zhu Y, Milton JT, Price DH (Apr 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409. 
  2. ^ Napolitano G, Licciardo P, Gallo P, Majello B, Giordano A, Lania L (Nov 1999). "The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity". AIDS 13 (12): 1453–9. doi:10.1097/00002030-199908200-00003. PMID 10465067. 
  3. ^ a b "Entrez Gene: CCNT2 cyclin T2". 
  4. ^ Simone, Cristiano; Bagella Luigi; Bellan Cristiana; Giordano Antonio (Jun 2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene (England) 21 (26): 4158–65. doi:10.1038/sj.onc.1205511. ISSN 0950-9232. PMID 12037672. 

Further reading[edit]

External links[edit]