Cyrrhestica (Greek: Κυρρηστική) is a district of Greater Syria which appears to have owed its name to the Macedonian occupation of the country. It lies between the plain of Antioch, and was bounded on the east by the Euphrates, and on the west by Amanus and Commagene; to the south, it extended as far as the desert. This fertile, well-watered, and thickly peopled district occupied the right bank of the Euphrates, where the river inclines rather eastward of south. It was the scene of the campaign in which Ventidius defeated the Parthian Pacorus and avenged Crassus and the Roman army which had fallen at Carrhae. Constantine I united it with Commagene under the name of Provincia Euphratensis. The chief towns of Cyrrhestica were Hierapolis Bambyce, Zeugma, Europus, Birtha?, Beroea (modern Aleppo), Batnae, and Cyrrhus.
This article incorporates text from a publication now in the public domain: Smith, William, ed. (1854–57). "article name needed". Dictionary of Greek and Roman Geography. London: John Murray.